Biological Resource Center. Fundação Oswaldo Cruz CRB-SAÚDE

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Luísa Miranda Salazar
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1 Biological Resource Center for Health Fundação Oswaldo Cruz CRB-SAÚDE

2 The start of BRC at Fiocruz: CLIOC May 2005 Workshop CRBs and Conformity Assessment for Biological Material In loco audits in the collections candidates to the accreditation (ISO 17025) Selection of collections able to accredited by INMETRO Establishement of the prototype of Brazilian CRB Network July Internal Auditing Training on ISO/17025: collections were selected: CLIOC - FIOCRUZ CBMAI - UNICAMP CENARGEN - EMBRAPA Banco de Células - UFRJ

accredited by INMETRO Establishement of the prototype of Brazilian CRB Network July 2005 - Internal Auditing

3 CLIOC: Model for the BRC at Fiocruz Activities developed within the BRC project Conclusion of the physical infra-structure (space remodelling) Establishment of the Quality Management System (NBR ISO 17025) Adequacy to the OECD guidelines Inventory process Definition of the ideal method for preservation and molecular techniques developed to determine the levels of intra-specific biodiversity Research Microsatelites Multi-locus sequencing typing Comparative genome Taxonomic markers Drug resistance markers Functional studies: growth curve, gene expression

the ideal method for preservation and molecular techniques developed to determine the levels of intra-specific biodiversity Research

4 CLIOC: Model for the BRC at Fiocruz Year of 2009 (Strains) CHARACTERIZED DEPOSITED DONNATED TOTAL = 369 Services offered by CLIOC to research development of vaccine and diagnostic kits projects production of diagnostic kits

Services offered by CLIOC to research development of

5 Bacteria Collections I. Coleções de Bactérias 1.1. Coleções de Bactérias do IOC: - Coleção de Culturas de Bactérias de Interesse em Saúde: - Enteropatógenos Bacterianos - Bactérias de Origem Hospitalar - Gênero Listeria - Gênero Campylobacter - Coleção de Culturas do Gênero Bacillus e Gêneros Correlatos - Coleção de Bactérias da Mata Atlântica 1.2. Coleções de Bactérias do IAM: - Coleção de Culturas de Yersinia - Coleção de Bactérias NB2 do IAM 1.3. Coleção de Microorganismos de Referência do INCQS Domínio Bactérias 1.4. Coleção de Bactérias da Amazônia do ILMD

Origem Hospitalar - Gênero Listeria - Gênero Campylobacter - Coleção de Culturas do Gênero Bacillus e Gêneros Correlatos - Coleção de

6 Fungi Collections II. Coleções de Fungos 2.1. Coleções de Fungos do IOC: - Coleção de Culturas de Fungos do IOC CCF/IOC - Coleção Micológica de Trichocomaceae 2.2. Coleção de Microorganismos de Referência do INCQS Domínio Fungos 2.3. Coleção de Fungos Patogênicos do IPEC 2.4. Coleção de Fungos da Amazônia do ILMD

7 Protozoa and Virus Collections IV. Coleções de Vírus III. Coleções de Protozoários 3.1. Coleções de Protozoários do IOC: - Coleção de Trypanosoma de Reservatórios Silvestres, Domésticos e Vetores - Coleção de Leishmania do IOC CLIOC/IOC 3.2. Coleções de Protozoários do IGM 4.1. Banco de Vírus do LAVITE do IAM 14 microbial collections

Coleções de Protozoários do IOC: - Coleção de Trypanosoma de Reservatórios

8 Microbial Collections FINEP/Modernit (2007) Coleção de Culturas do Gênero Bacillus e Gêneros Correlatos do IOC Coleção de Culturas de Bactérias de Interesse em Saúde do IOC Coleção de Culturas de Fungos do IOC Coleção Micológica de Trichocomaceae do IOC Coleção de Leishmania do IOC Coleção de Bactérias da Amazônia do ILMD Coleção de Fungos da Amazônia do ILMD

Coleção de Culturas de Fungos do IOC Coleção Micológica de Trichocomaceae do IOC Coleção

equipments Equipment substitution Sensitization process to optimize the use

9 Quality Environmental Project: Cleaner Research P+L water consumption Reverse osmosis Partnership with energy consumption Calibration of equipments Equipment substitution Sensitization process to optimize the use of equipments Paper recycling residues consumption Chemical management, storage and discard

10 Microbial Collections FINEP/CRB-FIOCRUZ (2008) Coleção de Culturas do Gênero Bacillus e Gêneros Correlatos do IOC Coleção de Culturas de Bactérias de Interesse em Saúde do IOC Coleção de Culturas de Fungos do IOC Coleção Micológica de Trichocomaceae do IOC Coleção de Bactérias da Amazônia do ILMD Coleção de Fungos da Amazônia do ILMD Coleção de Bactérias da Mata Atlântica do IOC Coleção de Trypanosoma de Reservatórios Silvestres, Domésticos e Vetores do IOC Coleção de Fungos Patogênicos do IPEC Coleção de Microrganismos de Referência do INCQS

Bactérias da Amazônia do ILMD Coleção de Fungos da Amazônia do ILMD Coleção de Bactérias da Mata Atlântica do IOC Coleção de Trypanosoma

11 Fiocruz Biological Fiocruz Biological Collections

12 Collection webpage s visibility on-line access to the service: strain identification, deposit and distribution Strain catalogue

13 Science & technology in health Biological and biomedical research: basic laboratory research; traditional disciplines (such as parasitology, microbiology, immunology, genetics, etc.) and new disciplines (such as genomics and pos-genomics), re- organized in complex scenario Public health research: health systems and services; epidemiology and surveillance Clinical research: studies on individual and group population; clinical assays Technological research: innovation in medicines, vaccines and diagnostic

) and new disciplines (such as genomics and pos-genomics), re- organized in complex scenario Public health research: health

14 Problems in C&T in health (1) National fragility on health innovation High dependency of knowledge generated on other countries Industry vulnerability of the health industrial complex Disarticulation among industrial, technological and health policies

countries Industry vulnerability of the health industrial

15 Problems in C&T in health Dissociation between research and burden of diseases (particularly concerning neglected diseases) Individual health prevails over collective health; Knowledge produced is scarcely utilized for policies and health program definition Deficient structure for biotechnology Weakness of the system for scientific production assessment Fiocruz must contribute to overcome this technological and economical gap with R&D and production

and health program definition Deficient structure for biotechnology Weakness of the system for scientific

16 Worldmapper: area of countries proportional to physicians working From C Morel, 2009

17 Worldmapper: area of countries proportional to HIV/AIDS prevalence From C Morel, 2009

18 Worldmapper: area of countries proportional to malaria cases From C Morel, 2009

19 The Sisyphus challenge in Chile Developing countries share disbelief about the benefits of the endogenous production of science as a tool for economical growth. Hence, public policies to strengthen science and technology and promote the culture of innovation are, in general, weak and sometimes incoherent Scientometrics 72(1):93-103, 2007 From C Morel, 2009

Hence, public policies to strengthen science and technology and promote the culture of

20 On-going initiatives in the country National Conferences on Science, Technology and Health Innovation (2000, 2004, 2010) National Agenda of Priorities on Health Research Private-Public Partnership (PPP) and Innovation Laws Innovation policy: pharmaceutic (BNDES) Creation of ABDI and INPI re-organization Competitiveness forum of Biotechnology Expansion of offer and quality of pos-graduation programs on health

and Innovation Laws Innovation policy: pharmaceutic (BNDES) Creation of ABDI and INPI re-organization

21 Fiocruz Response Production of: Vaccines of the National Immunization Program, in collaboration with Instituto Butantan (SP) Diagnostic kits for the main infectious disease Anti-retrovirals and drugs for controlling and treating the main endemies (malaria, TB, schistosomiasis, leishmaniasis, etc) Bio-drugs: α interferon, erythropoietin Medicines of continual use (hypertension, diabetes) Health-BRC

22 CRB-Saúde (Health-BRC) VISION To build a collection unique in the world of biological material related mainly to neglected diseases of Latin America in order to support scientific research, epidemiological studies, as well as the development and production of bioproducts directed to diagnosis vaccine and drugs.

23 CRB-Saúde (Health-BRC) MISSION To collect, preserve, indentify and catalogue, following international standards of Quality, a representative collection of microrganisms which are relevant to epidemiology surveillance, particularly those related to neglected diseases, and to the technological development of products human Health. with significance to

24 CRB-Saúde (Health-BRC) (Primary) scope Virus Bacterial cultures Fungi cultures Protozoa cultures

25 CRB-Saúde (Health-BRC) Staff Specialists in the following fields: microbiology, parasitology, genetics, cellular biology, molecular biology, and/or tropical medicine Topics of interest Taxonomy Evolution Molecular phylogeny Microbial diversity Molecular epidemiology Development and evaluation of cultivation and preservation methods

26 Working Plan for the BRC Network: Health-BRC Meta Etapa 1. Elaboração do Projeto CRB-Saúde 1.1. Definição de parcerias nacionais e estrangeiras 1.2. Participação em reuniões estratégicas 1.3. Chamada institucional para definir a composição do acervo 1.4. Visita e avaliação das coleções proponentes 1.5. Estruturação do projeto 2. Construção do prédio do CRB Licitação e contratação de empresa para elaboração dos Saúde projetos básico e executivo 2.2. Elaboração do projeto básico 2.3. Elaboração do projeto executivo 2.4. Licitação para a construção do prédio 2.5. Construção do Prédio 3. Aparelhamento do CRB-Saúde 3.1. Elaboração do Termo de Referência para licitação para aquisição dos equipamentos 3.2. Licitações para aquisição dos equipamentos 3.3. Aquisição e recebimento dos equipamentos 3.4. Instalação dos equipamentos

27 Proposal of a model for biological material management Health Centers, Outpatients units, Hospitals, universities PRE- ANALYTICAL BIOLOGICAL MATERIAL RECEPTION CENTER RESEARCH & TDI COLLECTIONS ANALYTICAL Lab Lab Lab Lab Lab Lab BRC POST- ANALYTICAL FINAL RESULT QUALITY CONTROL SVS Epidemiological surveillance

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