VIROLOGIA 2006/2007. APRESENTAÇÃO 7 (Vírus de RNA-) Maria Filomena Caeiro

Transcrição

1 VIROLOGIA 2006/2007 APRESENTAÇÃO 7 (Vírus de RNA-) Maria Filomena Caeiro

2 Cann, A. J. (1997). Principles of Molecular Virology. Academic Press, Inc.

3 RHABDOVIRIDAE Rhabdovirus de plantas: Potato yellow dwarf Lettuce necrotic yellows Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

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5 Cann, A. J. (1997). Principles of Molecular Virology. Academic Press, Inc.

6 Levy, J. A., Fraenkel-Conrat, H. and Owens, R. A. (1994). Virology. 3rd edition. Prentice-Hall, Inc.

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8 Cann, A. J. (1997). Principles of Molecular Virology. Academic Press, Inc.

9 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

10 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

11 Singer, M. and Berg, P. (1997). Exploring Genetic Mechanisms. University Science Books. Sausalito, California.

12 Ordem: Mononegavirales Família: Paramyxoviridae Sub-família: Paramyxovirinae Respirovirus Rubulavirus Morbilivirus Sub-família: Pneumovirinae Pneumovirus Metapneumovirus ICTV, 2000

13 TABLE 1 GENUS MEMBERS GLYCOPROTEINS Paramyxovirus human parainfluenza virus1 (HPIV 1) human parainfluenza virus3 (HPIV 3) HN, F Rubulavirus human parainfluenza virus2 (HPIV 2) human parainfluenza virus4 (HPIV 4) Mumps virus HN, F Morbillivirus measles H, F Pneumovirus respiratory syncytial virus G, F

14 Cann, A. J. (1997). Principles of Molecular Virology. Academic Press, Inc.

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16 Cann, A. J. (1997). Principles of Molecular Virology. Academic Press, Inc.

17 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

18 Singer, M. and Berg, P. (1997). Exploring Genetic Mechanisms. University Science Books. Sausalito, California.

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20 Singer, M. and Berg, P. (1997). Exploring Genetic Mechanisms. University Science Books. Sausalito, California.

21 Orthomyxoviridae Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

22 Orthomyxoviridae

23 Orthomyxoviridae

24 Vírus Influenza Três géneros (tipos): A, B, C Apenas o tipo A apresenta um largo espectro de hospedeiros Vírus Influenza A Subtipos definidos pelos antigénios de superfície H (hemaglutinina) e N (neuraminidase): 15 subtipos H e 9 subtipos N

25 Cann, A. J. (1997). Principles of Molecular Virology. 2nd edition. Academic Press, Inc.

26 Levine, A. J. (1992). Viruses. Scientific American Library.

27 HA NA HA e NA: Levine, A. J. (1992). Viruses. Scientific American Library. Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

28 HA Levine, A. J. (1992). Viruses. Scientific American Library.

29 Harper, D. R. (1998). Molecular Virology. 2nd edition. BIOS Scientific Publishers

30 Levine, A. J. (1992). Viruses. Scientific American Library.

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32 Influenza A/Seal/Mass/1/80 (H7N7) Fields, B. N. and Knipe, D. M. (1990). Virology. 2nd edition. Volumes 1 and 2. Raven Press.

33 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

34 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

35 1933 Isolamento do vírus em humanos 1935 Primeira vacina testada 1937 Produção da vacina Ensaios em grande escala da vacina Vacinação em massa Purificação da vacina Hemaglutinina e Neuraminidase são caracterizadas

36 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

37 Singer, M. and Berg, P. (1997). Exploring Genetic Mechanisms. University Science Books. Sausalito, California.

38 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

39 Singer, M. and Berg, P. (1997). Exploring Genetic Mechanisms. University Science Books. Sausalito, California.

40 Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. and Skalka, A. M. (2004). Principles of Virology. Molecular Biology, Pathogenesis, and Control. 2nd edition. ASM Press.

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