BCTRIMS. 15 th Annual Meeting. XV Congresso Brasileiro de Esclerose Múltipla e Neuromielite Óptica

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3 BCTRIMS 15 th Annual Meeting XV Congresso Brasileiro de Esclerose Múltipla e Neuromielite Óptica August 6-9, 2014 Royal Palm Plaza Resort Campinas - São Paulo, Brazil

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5 TABLE OF CONTENTS Welcome Message... 5 About BCTRIMS... 7 Committees List of Chairpersons and Speakers Scientific Programme Wednesday, August Thursday, August Friday, August Saturday, August Awards Instructions for Poster Presenters Instructions for Speakers General Information Social Event Venue Secretariat Travel Agency Campinas Posters Acknowledgements... 43

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7 WELCOME MESSAGE Dear Colleagues and Friends, It is our pleasure to have you present at the BCTRIMS 15 th Annual Meeting in Campinas-SP at the Royal Palm Plaza Resort. The focus of this meeting will be the mental and cognitive disorders in multiple sclerosis, for which we have the participation of leading experts in the area. One of the main objectives of BCTRIMS is to motivate research in Brazil, particularly in multiple sclerosis, neuromyelitis optica and correlated diseases, bringing the opportunity for presentation and discussion of research results, as well as for exchange of scientific experience. Therefore, it is an appropriate event for you to present your papers and compete for prizes. Do take this opportunity to discover Campinas, which is the second largest city in São Paulo State, one of the main business centers in the country and the technological pole in Latin America, having two big universities PUCC and UNICAMP. Campinas also has some attractions well worth visiting, such as the Taquaral Park, Bosque dos Jequitibás, Metropolitan Cathedral, and Carlos Gomes Square. In addition, there are many restaurants offering a range of cuisines with local and international flavors, as well as entertainment options including theater, movies and a rich nightlife with different types of bars and night clubs. Prof. Dr. Benito P. Damasceno Chairman of the BCTRIMS 15 th Annual Meeting BCTRIMS 15 th Annual Meeting 5

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9 ABOUT BCTRIMS BRAZILIAN COMMITTEE FOR TREATMENT AND RESEARCH IN MULTIPLE SCLEROSIS (BCTRIMS) President Secretary Treasurer Steering Committee Marco Aurélio Lana-Peixoto Jefferson Becker Dagoberto Callegaro Dagoberto Callegaro Paulo Diniz da Gama Marco Aurélio Lana-Peixoto Angelina Martins Lino Aílton Souza Melo Rogério de Rizo Morales Marcos Moreira Fernando Coronetti Rocha Jefferson Becker Irênio Gomes BCTRIMS 15 th Annual Meeting 7

10 THE ORIGINS OF BCTRIMS A group of Brazilian neurologists gathered together for a scientific symposium in the city of Botucatu, São Paulo state, on 28 August From this event emerged the foundation of the Brazilian Committee for Treatment and Research in Multiple Sclerosis(BCTRIMS), a national organization aimed at establishing a network of healthcare professionals interested in the field of multiple sclerosis and other demyelinating disorders of the central nervous system. Since its foundation, BCTRIMS has continued to grow, with current membership exceeding 300 colleagues from around the country, representing over 30 universities and medical schools in 22 Brazilian states. BCTRIMS MISSION The mission of BCTRIMS is to foster collaboration among clinicians and researchers throughout Brazil in order to implement studies and educational activities on multiplesclerosis and other demyelinating disorders of the central nervous system, as well as to develop strategies to influence healthcare providers so that the most effective actions for benefiting individuals affected by these diseases may be adopted. BCTRIMS GOALS To elucidate the epidemiology, genetics and clinical features of MS and other demyelinating diseases of the central nervous system in Brazil; To build a national MS registry and database; To build uniform protocols for research and stimulate cooperative studies in different regions of the country; To publish consensuses and guidelines for diagnosis and treatment of MS and other demyelinating disorders of the central nervous system; To promote continuing medical education activities; 8 BCTRIMS 15 th Annual Meeting

11 To stimulate and support young researchers within the field of MS; To organize and promote BCTRIMS Annual Meetigs; To represent Brazilian MS researchers in similar international committees; To interact with similar organizations throughout the world, in order to exchange experiences and promote collaborative actions; To assist and serve as a consultancy organization to Brazilian government agencies, in order to formulate strategies for healthcare within the field of MS and other demyelinating disorders of the central nervous system; To provide healthcare professionals and the lay community with information on MS pathogenesis, diagnosis and treatment. BCTRIMS ACHIEVEMENTS The Brazilian Committee for Treatment and Research in Multiple Sclerosis has had great success since it was established, and has achieved a number of noteworthy goals, including: Meetings with government officials to implement policies for benefiting MS patients, such as free disease-modifying therapy and multidisciplinary care; Assistance to government agencies in matters concerning evaluation of standards of quality of care delivered by MS centers in Brazil; Publication of Guidelines on Treatment of Multiple Sclerosis; Promotion of BCTRIMS Annual Meetings since its foundation in 1999; Promotion of scientific symposia and other educational activities; Publication of Fascículos de Esclerose Múltipla ; Stimulation and support for numerous scientific publications by its members in peerreviewed international medical journals; Creation of the BCTRIMS website: BCTRIMS 15 th Annual Meeting 9

12 COMMITTEES BCTRIMS 15 TH ANNUAL MEETING Chairman Benito Pereira Damasceno Organizing Committee Alfredo Damasceno Alessandro Farias Benito Pereira Damasceno Dagoberto Callegaro Jefferson Becker Leonardo de Deus Silva Leonilda M. B. Santos Marco Aurélio Lana-Peixoto Thiago de Faria Junqueira Plataform Presentation Award Committee Amit Bar-Or Benito Pereira Damasceno Marcelo Matiello Miguel Angel Macias Rosana H. Scola Tanuja Chitnis Tatsuro Misu Poster Session Award Committee Alfredo Dasmaceno Irênio Gomes Jefferson Becker Leonilda M. B. Santos Marcello Matiello Maria Fernanda Mendes 10 BCTRIMS 15 th Annual Meeting

13 LIST OF CHAIPERSONS AND SPEAKERS Aílton Melo Alessandro dos Santos Farias Alfredo Damasceno Amit Bar-Or André L. Muniz Alves dos Santos André Palma da Cunha Matta Benito Pereira Damasceno Carlos Augusto de A. Damasceno Carlos Otávio Brandão Carolina de Medeiros Rimkus Celso Luís Silva de Oliveira Cristiane Franklin Rocha Dagoberto Callegaro Dênis Bernardi Bichuetti Denise Sisterolli Diniz Doralina Guimarães Brum Souza Douglas Kazutoshi Sato elizabeth Regina Comini Frota emerson Leandro Gasparetto Ernane Maciel fabiana Christina Fernando felipe Von Glehn Silva fernando Cendes fernando Coronetti G. da Rocha fernando Faria Andrade Figueira Heloísa Helena Ruocco Irênio Gomes Salvador Campinas Campinas Canada Salvador Rio de Janeiro Campinas Juiz de Fora Campinas São Paulo Santos Belo Horizonte São Paulo São Paulo goiânia Ribeirão Preto Japan Belo Horizonte Rio de Janeiro Brasília São Paulo USA Campinas Botucatu Rio de Janeiro Campinas Porto Alegre BCTRIMS 15 th Annual Meeting 11

14 Jefferson Becker Juliana Machado S. S. Amaral Larissa Monteiro Leonardo de Deus Silva Leonardo Vedolin Leonilda M. B. Santos Lineu Cesar Werneck Marcelo Matiello Márcio Luiz Figueredo Balthazar Marco Aurélio Lana-Peixoto Marcus Vinícius Magno Gonçalves Maria Fernanda Mendes Maria Kamimura Maria Lúcia Brito Ferreira Marlise de Castro Ribeiro Miguel Angel Macias Mônica Koncke Fiuza Parolin natalia Cirino Talim Nívea de Macedo Oliveira Morales osvaldo J. M. do Nascimento Paulo Diniz da Gama Ricardo Nitrini Rodrigo G. Kleinpaul Vieira Rosana Hermínia Scola Rogério Rizo de Morales Samira Apóstolos Tanuja Chitnis Tarso Adoni Tatsuro Misu Thiago de Faria Junqueira Wellington Mendes Porto Alegre Belo Horizonte Salvador Campinas Porto Alegre Campinas Curitiba USA Campinas Belo Horizonte Joinville São Paulo São Paulo Recife Porto Alegre Mexico Curitiba Belo Horizonte Uberlândia Rio de Janeiro Sorocaba São Paulo Belo Horizonte Curitiba Uberlândia São Paulo USA São Paulo Japan Salvador São Paulo 12 BCTRIMS 15 th Annual Meeting

15 SCIENTIFIC PROGRAMME WEDNESDAY, AUGUST 6 02:00 pm Opening Session Benito Damasceno, Marco A. Lana-Peixoto, Jefferson Becker, Dagoberto Callegaro 02:15 pm BCTRIMS Workshop on Clinical Research Milestones in clinical research: From a good idea to paper publication Part I: Chairpersons: Benito Damasceno, Lineu Werneck, Aílton Melo Clinical Research in Brazil Wellington Mendes How to design a clinical research project Fernandes Cendes 04:00 pm Coffee break How to transform an idea into a paper? The structure of a project Background What am I trying to show? How to show it? How to interpret it? What does it mean? 04:30 pm BCTRIMS Workshop on Clinical Research Milestones in clinical research: From a good idea to paper publication Part II: Chairpersons: Dagoberto Callegaro, André Palma Matta, Natália Talim How to deal with the regulatory issues in clinical research Fabiana Cristina Fernando Plataforma Brasil The Local Ethical Committee ANVISA BCTRIMS 15 th th Annual Meeting 13

16 How to write and publish your paper: General rules Maria Kamimura Start choosing an attractive title The Abstract is the final part Intoduction: Here you say WHY you did your work Methods: Say HOW you did it Results: Present WHAT you observed when you did it Discussion: Comment on how your observations are related with the current knowledge and in which aspects they change it. The art of choosing the key references and how to manage them Choose the most appropriate periodical to submit your paper: Impact Factor and H-Index How to submit your paper; The online techniques How to answer to Reviewers queries THURSDAY, AUGUST 7 08:00 am Scientific Session: Chairpersons: Leonardo de Deus, Carolina Rimkus, Samira Apóstolos Conventional MRI and the diagnosis of MS: What changed after the 2010 revised criteria Leonardo Vedolin Monitoring MS therapy: The concept of sub-optimal response Fernando Figueira High-field and advanced MRI techniques in MS: Tips and pitfalls Emerson Gasparetto MRI and functional connectivity Fernando Cendes Comments Carolina Rimkus 10:00 am Coffee break 10:20 am Aluízio Marques Lecture Chairpersons: Alfredo Damasceno, Carlos Otávio Brandão, Thiago Junqueira 14 BCTRIMS 15 th Annual Meeting

17 Cognitive dysfunction in MS: Neuroscientific and neuropsychological basis of intervention Benito Pereira Damasceno 11:00 am ACTRIMS Lecture Chairpersons: Rosana Scola, Alessandro Farias, Denise Sisterolli Emerging roles of B cells throughout the MS Spectrum Amit Bar-Or (Canada) 11:30 am LACTRIMS Lecture Chairpersons: Mônica Parolin, Marcus Vinícius Gonçalves, Ernane Maciel Cognition in Latin American MS Miguel Angel Macías (Mexico) 12:00 am GENZYME SYMPOSIUM 01:00 pm BIOGEN SYMPOSIUM 02:00 pm Scientific Session: Topics in Multiple Sclerosis Chairpersons: Marcelo Matiello, Paulo Diniz da Gama, Fernando Coronetti PL-001 Prevalence of neuromyelitis optica in Belo Horizonte, Brazil Authors: Anderson Silva, Gisele O. Lima, Diogo C. Carvalho, Tauana S. Tironi, Izabela C. A. Duarte, Natália Cirino Talim, Lívia Edwiges Cirino Talim, Juliana M. S. S. Amaral, Rodrigo Kleinpaul, Márcia Prates, Carolina R. Araújo, Cristiane Franklin Rocha, Marco Aurélio Lana-Peixoto Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical School, Belo Horizonte, Minas Gerais, Brazil PL Suboptimal response to therapy in disease-free MS patients: A paradox? Authors: Fernando Faria Andrade Figueira, Gustavo Medeiros Andrade Figueira, Paula Vallegas Soares Institutions: Hospital São Francisco, Rio de Janeiro, Brazil PL-003 The incidence of multiple sclerosis in Joinville, Brazil Authors: Marcus Vinícius Magno Gonçalves, Norberto Luiz Cabral, Rafaela Bitencourt Liberato, Juliana Antunes Safanelli, Alexandre Luiz Longo, Carla Heloisa Cabral Moro Institutions: Clínica Neurológica e Neurocirúrgica de Joinville, Santa Catarina, Brazil BCTRIMS 15 th th Annual Meeting 15

18 PL-004 Aquaporin 4 IgG assays in Brazilian patients with neuromyelitis optica spectrum disorders Authors: Frederico M. H. Jorge, Douglas Sato, Samira Apóstolos-Pereira, Renata Simm, Paula Zago, Luana M. Oliveira, Gustavo Linhares, Dagoberto Callegaro Institutions: Hospital das Clinicas FMUSP, São Paulo, Brazil PL-005 Brainstem symptoms during the first attack of neuromyelitis optica spectrum disorders Authors: Frederico M. H. Jorge, Douglas Sato, Renata Simm, Samira Apóstolos-Pereira, Luana M. Oliveira, Mário L. R. Monteiro, Gustavo Linhares, Paula Zago, Dagoberto Callegaro Institutions: Hospital das Clinicas FMUSP, São Paulo, Brazil PL-006 Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks Authors: Douglas Kazutoshi Sato, Dagoberto Callegaro, Frederico Haidar Menucci Jorge, Ichiro Nakashima, Shuhei Nishiyama, Toshiyuki Takahashi, Renata Faria Simm, Samira Luisa Apóstolos-Pereira, Tatsuro Misu, Lawrence Steinman, Masashi Aoki, Kazuo Fujihara Institutions: Stanford University, Estados Unidos; Tohoku University, Japan; University of São Paulo, São Paulo, Brazil PL-007 Insulin resistance is correlated with disability in Neuromyelitis optica Authors: Wildea Lice Carvalho Jennings Pereira, Ana Paula Kallaur, Sayonara Rangel Oliveira, Andrea N. C. Simão, Lucas J. Schiavão, Paula R. V. P. Rodrigues, Edna M. V. Reiche, Damacio R. Kaimen-Maciel Institutions: Universidade Estadual de Londrina, Paraná, Brazil PL-008 Pathologic yawning in neuromyelitis optica spectrum disorders Authors: Marco Aurélio Lana-Peixoto, Dagoberto Callegaro, Natália Cirino Talim, Lívia Edwiges Cirino Talim, Samira A. Pereira, Gilberto Belisário Campos Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical School, Minas Gerais, Brazil; Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil PL-009 Properties of the research publications in neuromyelitis optica. The use of the web of science database Authors: Lívia Edwiges Cirino Talim, Natália Cirino Talim, Mariza C. T. 16 BCTRIMS 15 th Annual Meeting

19 Talim, Jane R. Guirado, Gisele O. Talim, Diogo C. Carvalho, Tauana S. Tironi, Izabela C. A. Duarte, Anderson Silva, Rodrigo Kleinpaul, Márcia Prates, Juliana M. S. S. Amaral, Carolina R. Araújo, Cristiane Franklin Rocha, Marco Aurélio Lana-Peixoto Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical School, Belo Horizonte, Minas Gerais, Brazil PL-010 The growth rate of scientific publications in neuromyelitis optica spectrum disorders Authors: Gisele de Oliveira Lima, Natália Cirino Talim, Lívia E. C. Talim, Rodrigo Kleinpaul, Márcia Prates, Diogo Couto de Carvalho, Tauana de Sousa Tironi, Izabela C. A. Duarte, Anderson F. Silva, Mariza C. T. Talim, Jane R. Guirado, Carolina Reis Araújo, Cristiane Franklin Rocha, Marco Aurélio Lana-Peixoto Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical School, Belo Horizonte, Minas Gerais, Brazil 04:00 pm Coffee break 04:30 pm Scientific Session: Topics in Multiple Sclerosis Chairpersons: Osvaldo Nascimento, Cristiane Franklin Rocha, Rogério de Rizo Morales PL-011 Clinical efficacy and safety of natalizumab in Brazilian patients with multiple sclerosis Authors: Renata Simm, Douglas Sato, Frederico M. H. Jorge, Samira Apóstolos-Pereira, Mirella Fazzito, Gustavo Linhares, Luana M. Oliveira, Dagoberto Callegaro Institutions: Hospital das Clínicas (FMUSP), São Paulo, Brazil PL-012 How can we detect balance problems in multiple sclerosis patients with low disability? Authors: Bruna Antinori-Vignola, Cristiana Borges Pereira, Dagoberto Callegaro Institutions: University of São Paulo, São Paulo, Brazil PL-013 Activation of plasmacytoid dendritic cells in neuromyelitis optica patients Authors: Marília Domingues Andrade, Felipe Von Glehn, Alliny Carolina Dionete, Adriel Santos Moraes, Carlos Otávio Brandão, Rafael P. C. D. Carneiro, Alfredo Damasceno, Fernando Pradella, Guilherme A. D. Morais, Paula Giovana Russini, Alessandro S. Farias, Benito P. Damasceno, Charles P. Tilbery, Leonilda Maria Barbosa Santos BCTRIMS 15 th th Annual Meeting 17

20 Institutions: Universidade Estadual de Campinas (Unicamp), São Paulo, Brazil PL-014 Administration of embryonic stem cells attenuates the development of experimental autoimmune encephalomyelitis Authors: Paula Giovana Russini, Talita Glaser, Rosemeire Florença de Paula, Mariana Peres Almeida Santos, Fernando Pradella, Gleigy Ana Araújo Silva, Elaine Conceição de Oliveira, Alessandro Santos Farias, Alexander Henning Ulrich, Leonilda Maria Barbosa Santos Institutions: Universidade Estadual de Campinas (Unicamp), São Paulo, Brazil; Universidade Estadual de São Paulo (USP), São Paulo, Brazil PL-015 Correlation between serum markers and scores of disease severity and fatigue in neurologically stable multiple sclerosis patients under therapy with interferon beta-1a Authors: Giordani Rodrigues Passos, Irênio Gomes, Adriana Gutterres Pereira, André Palma da Cunha Matta, Bruna Schilling Panizzutti, Clarissa Severino Gama, Flávio Pereira Kapczinski, Helena Fussiger, Juliana Castilhos Beauvalet, Luciana Schermann Azambuja, Osvaldo Nascimento, Jefferson Becker Institutions: Antônio Pedro University Hospital Federal Fluminense University, Rio de Janeiro, Brazil; São Lucas Hospital Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil PL-016 Differential oxidative stress and cytokine profile between progressive and relapsing-remitting multiple sclerosis patients Authors: Ana Paula Kallaur, Sayonara Rangel Oliveira, Andrea Name Colado, Helena Kaminami Morimoto, Daniele Frizon Alfieri, Paula Raquel do Vale Pascoal Rodrigues, Lucas José Vaz Schiavão, Karimy Sayuri Nagata Maekawa, Danilo Macedo Grotti, Douglas Francisco Rodrigues, Francieli Delongui, Damácio Ramon Kaimen-Maciel, Edna Maria Vissoci Reiche Institutions: State University of Londrina, Paraná, Brazil PL-017 Effect of type I interferon in the tolerogenic function of plasmacytoid dendritic cells in experimental autoimmune encephalomyelitis Authors: Mariana Peres Almeida Santos, Ana Leda F. Longuini, Rosemeire O. Paula, Paula G. Russini, Fernando Pradella, Adriel S. Moraes, Guilherme A. D. Morais, Alessandro S. Farias, Leonilda M. B. Santos Institutions: Universidade Estadual de Campinas (Unicamp), São Paulo, Brazil 18 BCTRIMS 15 th Annual Meeting

21 PL-018 Natalizumab increases hla-g expression in pdcs of multiple sclerosis patients Authors: Alliny Carolina Dionete, Adriel Santos Moraes, Marília Domingues Andrade, Alfredo Damasceno, Felipe Von Glehn, Leonilda Maria Barbosa Santos Institutions: Unicamp, São Paulo, Brazil PL-019 Respiratory impairment is associated with fatigue in patients with relapsing-remitting multiple sclerosis Authors: Fernanda Machado Taveira, Renan Barros Domingues, Antônio Lúcio Teixeira Júnior Institutions: Federal University of Minas Gerais (UFMG), Minas Gerais, Brazil PL-020 Tumor necrosis factor beta (TNFB) NcoI polymorphism is associated with serum cytokine and adiponectin levels in relapsingremitting multiple sclerosis patients Authors: Ana Paula Kallaur, Sayonara Rangel Oliveira, Andrea Name Colado Simão, Helena Kaminami Morimoto, Daniele Frizon Alfieri, Wildea Lice de Carvalho Jennings Pereira, Paula Raquel do Vale Pascoal Rodrigues, Lucas José Vaz Schiavão, Karimy Sayuri Nagata Maekawa, Danilo Macedo Grotti, Douglas Francisco Rodrigues, Damácio Ramon Kaimen-Maciel, Edna Maria Vissoci Reiche Institutions: State University of Londrina, Paraná, Brazil 08:00 pm Gala Dinner friday, AUGUST 8 08:00 am Poster Session: Presentation and discussion Epidemiology and MRI Panel 1: Alfredo Damasceno, Carolina Rimkus, Fernando Figueira, Leandro Lucatto, Aílton Melo Immunology and basic science of MS Panel 2: Amit Bar-Or, Leonilda M.B. Santos, Alessandro Farias, Elizabeth Comini Frota BCTRIMS 15 th th Annual Meeting 19

22 NMO, ADEM, CIS Panel 3: Tanuja Chitnis, Tatsuro Misu, Marcelo Matiello, Lineu César Werneck MS treatment and multidisciplinary care Panel 4: Maria Fernanda Mendes, Larissa Monteiro, Heloísa H. Ruocco, Tarso Adoni 10:00 am Coffee break 10:20 am Top 10 of the Year: How the best papers impact our practice Jefferson Becker, Dênis Bichuetti Panel: Tatsuro Misu, Amit Bar-Or, Tanuja Chitnis, Alfredo Damasceno 12:00 am NOVARTIS SYMPOSIUM 01:00 pm NOVARTIS SYMPOSIUM 02:00 pm Scientific Session: Devic s neuromyelitis optica Chairpersons: Dagoberto Callegaro, Marcelo Matiello, Rodrigo Kleinpaul Pathology of NMO spectrum disorders Tatsuro Misu (Japan) What does MOG-IgG in NMO patients mean? Douglas Sato (Japan) The International Diagnostic Criteria for NMO spectrum disorders Marco A. Lana-Peixoto Diagnosis and management of pediatric NMO Tanuja Chitnis (USA) Comments and discussion Marcelo Matiello (USA) 04:00 pm Coffee break 04:30 pm Awards Presenting Session Chairpersons: Benito Pereira Dasmaceno, Marco A. Peixoto-Lana, Jefferson Becker, Leonilda M. B. Santos 20 BCTRIMS 15 th th Annual Meeting

23 BCTRIMS Aluízio Marques Award BCTRIMS Roberto Melaragno Filho Award BCTRIMS Gilberto Belisário Campos Young Investigator Award BCTRIMS Genzyme Award for Excellence in Scientific Production 04:40 pm Scientific Session: Cognitive dysfunction in Multiple Sclerosis Chairpersons: André Muniz, Maria Lúcia Brito, Marlise de Castro Ribeiro Cognitive dysfunction in MS: methodological issues and measurement with current and future batteries. Benito Pereira Damasceno MRI predictors of cognitive dysfunction Alfredo Damasceno Cognitive reserve as a protective factor Ricardo Nitrini Comments and discussion Márcio Luiz Figueredo Balthazar saturday, AUGUST 9 08:00 am Scientific Session: What is new in immunology of demyelinating diseases of the CNS Chairpersons: Carlos Augusto Damasceno, Celso Luis Silva de Oliveira, Juliana Santiago Amaral Plasmocytoid dendritric cellls in multiple sclerosis Leonilda M. B. Santos Immunomodulatory Effect of vitamin D3 Alessandro dos Santos Farias CSF Oligoclonal Bands Disappearance: How could it impact MS brain cortical layer atrophy? Felipe von Glehn 10:00 am 6 th BCTRIMS Colloquium on MS and NMO Research Irênio Gomes, Jefferson Becker, Dagoberto Callegaro, Marco A. Lana-Peixoto, Doralina Brun BCTRIMS th th Annual Meeting 21

24 Works in Progress 1. Vitamin D in multiple sclerosis: A Brazilian Study 2. Studies in regulatory proceedings Call for New Studies 1. Cognition in Mutiple Sclerosis. A Multicenter Brazilian Study Alfredo Damasceno 2. Brazilian Protocol for MRI Study in Demyelinating Diseases of the Central Nervous System Carolina Rimkus, Fernando Figueira, Emerson Gasparetto, Leonardo Vedolin 11:00 am BCTRIMS Multicentric Research Groups Meeting MS Epidemiology Study Group Marco A. Lana-Peixoto NMO in Children André Palma Matta Vitamin D Study Group Dagoberto Callegaro Pediatric MS Study Group Nívea de Macedo O. Morales Neuroradiology Study Group Carolina Rimkus Cognition Study Group Benito Pereira Damasceno 12:00 am Closing Session and Invitation for the BCTRIMS 16 th Annual Meeting 2015 Benito Pereira Damasceno, Marco A. Lana-Peixoto, Dagoberto Callegaro, Jefferson Becker, Irênio Gomes 22 BCTRIMS th th Annual Meeting

25 AWARDS BCTRIMS Aluízio Marques Award The Aluízio Marques Award is given to the best poster presented at the BCTRIMS Annual Meeting. Multiple sclerosis was first described in Latin America by Aluízio Marques, in At the time Marques a young medical student at University of Brazil, in Rio de Janeiro. During his vacations and a visit to a hospital ward in Recife, where his uncle Juan Marques delivered medical care and taught Internal Medicine, he observed a patient with spastic paralysis, nystagmus, and intention tremor, the characteristics clinical triad of the disease, as he had learned from Charcot s writings. His observations were then published in Jornal de Medicina, in Pernambuco. With a special interest in disease of the central nervous system Aluízio Marques made a lot of important contributions to Brazilian neurology. In 1943 he described the first cases of Devic s neuromyelitis optica in Latin America. Bctrims Roberto Melaragno Filho Award The Roberto Melaragno Filho Award is given to the best poster for Multidisciplinary Care presented at the BCTRIMS Annual Meeting. BCTRIMS 15 th Annual Meeting 23

26 Roberto Melaragno Filho graduated from the School of Medicine of the University of São Paulo in 1942, before joining the Neurology Department at the university the following year as a Volunteer Assistant. He later went on to Paris, where he trained extensively in neurology under Professor Raymond Garcin. In 1963, upon his return to Brazil, he founded the Neurology Department at the São Paulo State Hospital, where he remained as Chairman until his retirement in During this time, he received countless accolades for his work there from all over the country, and he spent much of his time giving lectures and disseminating knowledge to fellow physicians regarding the art of diagnosing and treating MS and other demyelinating disorders of the central nervous system. He was a founding member of the Brazilian Academy of Neurology and helped establish the Brazilian Association of Multiple Sclerosis (ABEM), as well as being a member of many editorial boards. He was the author of numerous scientific papers and, in addition, published several neurology textbooks and a book aimed at MS patients. Professor Melaragno gained many awards over the course of his lifetime and it is with great honor and respect that the BCTRIMS dedicate this most celebrated award in his memory. Bctrims Gilberto Belisário Campos Young Investigator Award The Gilberto Belisário Campos Young Investigator Award is a research incentive prize given to the best platform presentation made at the BCTRIMS Annual Meeting. This award is offered by BCTRIMS, in collaboration with Novartis, and comprises of a diploma and sponsorship to annual the ACTRIMS/ECTRIMS Meeting. 24 BCTRIMS 15 th Annual Meeting

27 Gilberto Belisário Campos graduated from the School of Medicine at the Federal University of Minas Gerais (Universidade Federal de Minas Gerais - UFMG) in 1958, and subsequently pursued his training there in neurology and neurosurgery at the Hospital das Clínicas, UFMG. In 1959, he continued his studies at the University of Wisconsin, USA, where he graduated in basic neurological sciences, under the supervision of C. Woolsey, F. Forster and M. Javid. Together with C. Woolsey and W. I. Welker, he went on to conduct several prominent researches, nowadays considered classics, related to comparative studies of the organization of sensory and motor areas (mapping) by anatomical and electrophysiological methods, involving various animal species. He returned to Brazil in late 1963, where he began academic activities in the Neurology Department of the School of Medicine, UFMG. Gilberto Belisário Campos was responsible for the beginning of comparative experimental neurophysiological research within Brazil. He retired in 1991, and in 1997 he was elected Professor Emeritus at the School of Medicine of the Federal University of Minas Gerais. BCTRIMS is deeply honored to dedicate this award to his memory. Bctrims Genzyme Award for Excellence in Scientific Production Unrestricted educational grant given to the MS Center that presents the highest number of works at the Meeting. BCTRIMS 15 th Annual Meeting 25

28 INSTRUCTIONS FOR POSTER PRESENTERS The following information is intended to guide poster presenters for the Poster Discussion Session which will be held on August 8 at 8:00 am. Each Poster will be discussed by a Panel of Experts following its presentation by one of its authors. Questions by the audience may follow. As a poster presenter, please pay attention to the following requirements: You must disclose any financial interest that you (or your spouse/partner) may have with a commercial company or the manufacturer of any commercial product/service that may influence your presentation; Present your message objectively, spending no longer than 3 minutes; Emphasize the objectives; Do not detail the methodology; Summarize the results; Emphasize the conclusions; Answer the questions from the Panel and the audience cordially. INSTRUCTIONS FOR SPEAKERS The following information is intended to guide speakers towards developing their presentations. As a member of our faculty, you must meet some requirements. Please pay attention to the following: You must disclose any financial interest that you (or your spouse/partner) may have with a commercial company or the manufacturer of any commercial product/service that may influence your presentation; Make sure that your objectives and message are appropriate for the audience; Emphasize the points that you wish the audience to take away with them; Ensure that your visual aids will not overwhelm the audience or take their attention away from your core message; 26 BCTRIMS 15 th Annual Meeting

29 Try not to read from your slides; speak conversationally; Align your message according to the available time. You should estimate that it will take you approximately a minute to discuss each slide; A 5-minute time at the end of each presentation is reserved for discussion; Invite the audience to ask you questions. Answer them cordially. GENERAL INFORMATION Abstracts Abstracts of all posters accepted for presentation are published in English in the Arquivos de Neuro-Psiquiatria, the Official Journal of the Brazilian Academy of Neurology. Language English and Portuguese are the official languages of the congress. All posters and PowerPoint slides will be presented in English. Oral presentations may be presented either in Portuguese or in English. Simultaneous translation is not available. Meals The registration fee includes coffee breaks, lunch box (first come, first served) and admission to the Gala Dinner. Mobile phones The Organizing Committee kindly requests that participants should turn cellular devices and pagers to vibration mode upon entering official program sessions, satellite symposia, exhibits and social functions. No Smoking Smoking is prohibited in the scientific sessions, exhibitions and Gala Dinner. Speaker s Service Center (SSC) A Speaker s Service Center (SSC) is available for convenience. All speakers are kindly requested to hand in their PowerPoint presentations at the SSC at least 2 hours before their lecture. Tourist Information The tourist information desk, which is located next to the Congress Secretariat, will be available to help you to book tour tickets or make restaurant reservations, or to assist you in any other way. BCTRIMS 15 th Annual Meeting 27