CURRICULUM VITAE Florbela Carvalheiro

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1 CURRICULUM VITAE Florbela Carvalheiro Full name: Florbela de Oliveira Carvalheiro Esteves Amaro Birth place and date: Palmela, 25/04/1968 Nationality: Portuguese Institutional Address: Laboratório Nacional de Energia e Geologia, I.P. (LNEG), Unidade de Bioenergia, Estrada do Paço do Lumiar, 22, Ed. K2, Lisboa, Portugal Living address: R. Joaquim Agostinho, 10 4ºC, Lisboa Contact: (Tel); (mobile); (Fax) florbela.carvalheiro@lneg.pt Degrees PhD in Agro-Industrial Engineering, Technical University of Lisbon (ISA/UTL), Portugal (2006) Master in Science and Food Technology, Technical University of Lisbon, Portugal (1997) Undergraduate degree (Licenciatura) in Biological Engineering, University of Minho, Portugal (1992) Current and previous positions Researcher at LNEG (ex-ineti), since 14/11/2006 Research Assistant at INETI ( ) Research Trainee at INETI ( ) Fellow (BTI grant) at INETI, Praxis project BIO/1133/95 ( ) Master Student (JNICT fellowship) ( ) INETI fellow (1994) PEDIP fellow (JTI grant) at INETI ( ) Area of scientific activity Chemical Engineering and Biotechnology Domain of specialization Biorefining of lignocellulosic-based by-products Microbial physiology Present research interests Biorefining of lignocellulosic materials. Research activities in the bioenergy domain, particularly chemical biomass pre-treatments and bioconversion lignocellulosic hydrolysates (added-value products, liquid biofuels) aiming an integrated upgrading in the biorefineries framework. Kinetic modelling of the hydrolysis processes. Hemicelluloses upgrading in particular for the production of oligosaccharides and xylitol. Lignin upgrading. Physiology studies of biotechnological processes involving yeasts. Participation in research projects CropBioRef - Valorization of the Mediterranean energy crops giant reed and cardoon by integrated biochemical conversion to dissolving grade pulps, fuel ethanol, xylitol and lignin-based products a complete LCF biorefinery concept, PTDC/AGR-CFL/ ( ). REFINOLEA Integrated upgrading of olive oil extraction residues, QREN ( ). BIOREFINO - Demonstrating the feasibility of wheat straw and sweet sorghum biomass fermentation to ethanol using the biorefinery approach, PTDC/AGR-AAM/71533/2006 ( ). XILITOLOUT - To promote xylitol release to improve bioethanol business, PTDC/AGR-CFL/71792/2006 ( ). VALORALFA Upgrading of carob pulp for the production of food ingredients with functional properties with high added-value, AdI, Ideia Programme ( ). Valorisation of used tyres, plastics and biomass wastes by pyrolysis to produce valuable end products, POCTI/ENR/63388/2004 ( ). 1

2 XILOGASTRO - Purified Xylo-oligosaccharides as anti-ulcerative agents, AdI, ICPME Programme ( ). Materials and products with new functionalities, PIDDAC Project ( ). Upgrading of Brewery s By-products, Research Contract with BIOEID ( ). The Use of New Xylo-oligosaccharide in the Weaning Diet of Piglets and Rabits: Effect on the Intestinal Microflora and Digestive Physiology, POCTI/CVT/37545/02 ( ). "Development of Xylo-oligosaccharides and Xylitol for use in Pharmaceutical and Food Industry", FAIR CT ( ). EXPOBANANA - Exploitation of Banana Tree By-products", AdI, ICPME Programme ( ). ECOCOURO Optimization of the leather industry production process in a perspective of by-products recovery and pollutants reduction, PEDIP PM/418/98/073 ( ). "Recycling and Saccharification of Cellulose Fibres by Enzymes, PRAXIS XXI/2/21/BIO/1133/95 ( ). "Knowledge-Based Control and Operation of Industrial Productive Bioprocesses", COP-94/01217 ( ). "Dietary Fibers: Structural and Physical Properties of Dietary Fibers and Consequences of Processing on Human Physiology" (PROFIBRE), AIR3CT94/2203 ( ). "Metabolic Aspects of Technological Xylitol Production, JNICT/PBICT/C/BIO/1238/92 ( ). "Dietary Fibre Reference Materials", Industrial and Materials Technologies/Measurements and Techniques (BCR), MAT1-CT ( ). "Biotechnological Improvement of Tomato Pomace", SINPEDIP ( ). Member of the following networks SIADEB - Ibero-American Society for the Development of the Biorefineries, Cyted network, P309RT0350 ( ). EERA European Energy Research Alliance, Joint Research Program on Bioenergy: Sub-programme Sugar platform on NextGen Biofuels for Transport ( ). EERA European Energy Research Alliance, Joint Research Program on Bioenergy: Sub-programme Thermo-chemical Processing of Biomass ( ). BIOVALOR: Hemicelluloses Biotechnology industrial, food and pharmaceutical biomolecules obtained from lignocellulosic by-products, Cyted network, Iberoeka Programme, IBK ( ). CEBio - Competence Network in Bioenergy, AdI, POS_conhecimento Programme ( ). Prizes and distinctions Green Project Awards 2010, VALORALFA Project Winner on I&D category. Teaching and Supervising Experience Supervision of 22 (graduate and undergraduate) students PhD supervision of Patrícia Moniz ( Fractionation of agro-industrial residues to obtain high quality hemicelluloses and lignin to an integrated upgrading in a biorefinery framework ) ongoing ( ). Invited Teacher: - Degree in Food Engineering (Food Biotechnology), Instituto Piaget (2009/2010). - Seminars for the Master in Bioenergetic Systems Engineering (Biofuels), UTL (ISA e IST) and UL (FC) (2008/2009 and 2009/2010). - Master in Analytical Chemistry (Biotechnological Processes), University of Évora (2002/2003). - Degree in Biochemistry (Chemical Conversion of Biomass), University of Évora (2001/2002). Other activities Coordinator of Biomass Deconstruction Programme (LNEG) Founder s Council membership of SIADEB ( Ibero-American Society for the Development of the Biorefineries ) 2

3 Reviewer of 31 papers (since 2003) for the journals: Appl Biochem Biotechnol, Biomass & Bioenergy, Fuel, Ind Eng Chem Res, Biochem Eng J, J Agric Food Chem, Ind Crops Prod, Bioresources, Chem Eng J and Biores Technol. Member of the Editorial Board of Brazilian Journal of Food and Nutrition. Member of the Organizing Committee: - Advanced course SIADEB: Transforming biomass in the biochemical biorefinery platform, Universidade de S. Paulo, Lorena, Brazil, 29 th November-3 rd December "7 as Jornadas de Biologia de Leveduras - Professor Nicolau van Uden, INETI, Lisboa, May "European Symposium on Functional Properties of Non-Digestible Carbohydrates: Technology and Health Interactions", Lisboa, 5-7 March Publications Thesis Carvalheiro, F. (2005) Production, characterisation and biotechnological production of oligosaccharide liquors from brewery s spent grain. PhD Thesis (ISA/UTL). Carvalheiro, F. (1997) Technology of yeast production with industrial food application: optimization of xylitol accumulation by Debaryomyces hansenii and trehalose by Saccharomyces cerevisiae. MSc thesis (UTL). Papers in scientific periodicals with referees Carvalheiro, F., Moniz, P., Duarte, L.C., Esteves, M.P., Gírio, F.M. (2011) Mannitol production by lactic acid bacteria grown in supplemented carob syrup. J. Ind. Microbiol. Biotechnol. 38, Santos, J..L.C., Fernandes, M.C., Lourenço, P.M.L., Duarte, L.C., Carvalheiro, F., Crespo, J.G. (2011) Removal of inhibitory compounds from olive stone autohydrolysis liquors by nanofiltration, Desalination and Water Treatment, 27, Gírio, F.M., Fonseca, C., Carvalheiro, F., Duarte, L.C., Marques, S., Bogel-Lukasic, R. (2010) Hydrolysis of Hemicelluloses for Fuel Ethanol: a review. Biores. Technol., 101, Carvalheiro, F., Silva-Fernandes, T., Duarte, L.C., Gírio, F.M. (2009). Wheat straw autohydrolysis: process optimization and products characterization. Appl. Biochem. Biotechnol., 153, Duarte, L.C., Silva-Fernandes, T., Carvalheiro, F., Gírio, F. M. (2009). Dilute acid hydrolysis of wheat straw oligosaccharides. Appl. Biochem. Biotechnol., 153, Carvalheiro, F., Duarte, L.C., Gírio, F. M. (2008). Hemicellulose Biorefineries: a review on biomass pretreatments (2008) J. Scientific & Ind. Res., 67, Duarte, L.C., Carvalheiro, F., Lopes, S., Neves, I., Gírio, F. M. (2008) Yeast biomass production in brewery s spent grains hemicellulosic hydrolysate. Appl. Biochem. Biotechnol. 145, Carvalheiro, F., Duarte, L.C., Medeiros, R., Gírio, F. M. (2007) Xylitol production by Debaryomyces hansenii CCMI 941 in brewery s spent grain dilute-acid hydrolysate: effect of supplementation. Biotechnol. Lett. 29, Duarte, L.C., Esteves, M.P., Carvalheiro, F., Gírio, F. M. (2007) BVPI Biotechnological Valorization Potential Indicator for Lignocellulosic Materials. Biotechnol. J.. 2, Duarte, L.C., Esteves, M. P., Carvalheiro, F., Vicente, P., Gírio, F. M. (2007) Os subprodutos agro-industriais de natureza lenhocelulósica: caracterização da situação portuguesa. Engenharia Química, 5, Moura, P., Barata, R., Carvalheiro, F., Gírio, F., Loureiro-Dias, M.C., Esteves, M.P. (2007) In vitro fermentation by probiotic bacteria of xylo-oligosaccharides produced by corn cobs autohydrolysis. LWT, 40, Carvalheiro, F., Duarte, L.C., Lopes, S., Parajó, J. C., Pereira, H., Gírio, F. M. (2006) Supplementation requirements of brewery s spent grain hydrolysate for biomass and xylitol production by Debaryomyces hansenii CCMI 941. J. Ind. Microbiol. Biotechnol., 33, Duarte, L.C., Carvalheiro, F., Tadeu, J., Gírio, F.M. (2006) The combined effects of acetic acid, formic acid and hydroquinone on Debaryomyces hansenii physiology. Appl. Biochem. Biotechnol. 130, Carvalheiro, F., Garrote, G., Parajó, J. C., Pereira, H., Gírio, F. M. (2005) Kinetic modeling of brewery s spent grain autohydrolysis. Biotechnol. Prog., 21,

4 Duarte, L.C., Carvalheiro, F., Neves, I., Gírio, F.M. (2005) The effects of aliphatic acids, furfural and phenolic compounds in Debaryomyces hansenii CCMI 941. Appl. Biochem. Biotechnol., , Carvalheiro, F., Duarte, L. C., Lopes, S., Parajó, J. C., Pereira, H., Gírio, F. M. (2005) Evaluation of detoxification methods on brewery s spent grain hydrolysate for xylitol production by Debaryomyces hansenii CCMI 941. Proc. Biochem. 40, Carvalheiro, F., Duarte, L.C., Medeiros, R., Gírio, F.M (2004) Optimization of brewery s spent grain dilute-acid hydrolysis for the production of pentose-rich culture media. Appl. Biochem. Biotechnol., , Duarte, L.C., Carvalheiro, F., Lopes, S., Marques, S., Parajó, J.C., Gírio, F.M. (2004) Comparison of two posthydrolysis processes of brewery s spent grain autohydrolysis liquor to produce a pentose-containing culture media. Appl. Biochem. Biotechnol , Carvalheiro, F., Esteves, M.P., Parajó, J.C., Pereira, H., Gírio, F.M. (2004) Production of oligosaccharides by autohydrolysis of brewery s spent grain. Biores. Technol. 91, Kabel, M.A., Carvalheiro, F., Garrote, G., Avgerinos, E., Koukios, E., Parajó, J.C., Gírio, F.M., Schols, H.A., Voragen, A.G.J. (2002) Hydrothermally treated xylan rich by-products yield different classes of xylooligosaccharides. Carbohydr. Polym. 50, Carvalheiro, F., Roseiro, J. C, Gírio, F. M. (1999) Interactive effects of sodium chloride and heat shock on trehalose accumulation and glycerol production by Saccharomyces cerevisiae. Food Microbiol. 16, Tadeu-Pontes, M.A., Carvalheiro, F., Roseiro, J.C., Amaral-Collaço, M.T. (1995) Evaluation of product composition profile during an extrusion based process of tomato pomace transformation. Agro-Food Industry HI-Tech, May/June, Carvalheiro, F., Roseiro, J. Carlos, Amaral-Collaço, M. T. (1994) Biological conversion of tomato pomace by single and mixed fungal cultures. Proc. Biochem., 29, Book Chapters Temudo, M.S., Nunes, M.C., Batista, A..P., Carvalheiro, F., Esteves, M.P., Raymundo, A. (2008) Physicochemical characterisation of psyllium fibre, Gums and Stabilisers for the Food Industry 14, Vol. 316, Williams, Peter A.; Phillips, Glyn O. (Eds.), pp Patents Carvalheiro, F., Moniz, P., Duarte, L.C., Esteves, M.P., Moura, P., Pereira, J., Gírio, F.M., Roseiro, M.L., Gil, M.G.B. (2010) Processo para a produção de manitol por fermentação de um extracto aquoso da polpa de alfarroba triturada. PT Nº Moura, P., Esteves, M.P., Duarte, L.C., Pereira, J., L.C., Carvalheiro, F., Roseiro, M.L., Gírio, F.M., Gil, M.G.B. (2010) Bebida polifuncional não-alcoólica obtida por fermentação do extracto aquoso da polpa de alfarroba triturada e processo para a sua preparação. PT Nº Gil, M.G.B., Roque, R., Esteves, M.P., Duarte, L.C., Roseiro, M.L., Gírio, F.M, Carvalheiro, F., Moura, P., (2010). Produtos naturais antioxidantes obtidos por extracção supercrítica aplicada à fracção insolúvel que fica após a extracção com água da polpa de alfarroba triturada e seu método de produção. PT Nº Gírio, F.M, Carvalheiro, F., Esteves, M.P., Amaral Collaço, M.T., Parajó, J.C., Domínguez, H., Alonso, J.L., Vázquez, M.J., Garrote, G., Koukios, E.G., Avgerinos, E.S., Voragen, A.G.J., Schols, H.A, Kabel, M.A. (2003) Processo para a produção de xilo-oligossacáridos substituídos e sua utilização na indústria alimentar, química e energética. PT Gírio, F.M, Cruz, E.M., Amaral-Collaço, M.T., Corvo, M.L., Esteves, M.P., Carvalheiro, F., Moura, P., Lourenço, P., Carvalheiro, M.C., Simões, S., Voragen, A.G.J., Schols, H.A, Kabel, M.A. (2003) Processo para a preparação de oligossacáridos com actividade anti-ulcerativa e sua utilização para a preparação de medicamentos. PT Amaral-Collaço, M.T., Tadeu-Pontes, M.A., Carvalheiro, F. (1999) Processo para a preparação de um fermentado ou granulado rico em fibras alimentares e produto obtido por esse processo. PT Amaral-Collaço, M.T., Carvalheiro, F., Beirão da Costa, M.L., Silva, J., Empis, J. Tadeu-Pontes, M.A (1998) Processo para a preparação de produto extrudido rico em fibras alimentares e produto obtido por esse processo. PT Papers in conference proceedings: 10 Oral communications by invitation: 10 Other oral communications: 7 Posters in conferences: 54 4

5 Scientific Societies - SIADEB-Sociedade Ibero-Americana para o Desenvolvimento das Biorrefinarias (Founder s Council membership, 2010). - Sociedade Portuguesa de Biotecnologia (Membership, since 1992). September 2011, Florbela Carvalheiro 5