6 Só será permitido o uso de dicionário INGLÊS/INGLÊS.

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1 Confira se os dados contidos na parte inferior desta capa estão corretos e, em seguida, assine no espaço reservado para isso. Se, em qualquer outro local deste Caderno, você assinar, rubricar, escrever mensagem, etc., será excluído do Exame. Este Caderno contém 5 questões discursivas referentes à Prova da Língua Estrangeira escolhida pelo candidato. Não destaque nenhuma folha. Se o Caderno estiver incompleto ou contiver imperfeição gráfica que impeça a leitura, solicite imediatamente ao Fiscal que o substitua. Será avaliado apenas o que estiver escrito no espaço reservado para cada resposta, razão por que os rascunhos não serão considerados. Escreva de modo legível, pois dúvida gerada por grafia, sinal ou rasura implicará redução de pontos. 6 Só será permitido o uso de dicionário INGLÊS/INGLÊS. 7 A Comperve recomenda o uso de caneta esferográfica, confeccionada em material transparente, de tinta preta. Em nenhuma hipótese se avaliará resposta escrita com grafite. 8 Utilize para rascunhos, o verso de cada página deste Caderno. 9 Você dispõe de, no máximo, três horas, para responder as 5 questões que constituem a Prova. 10 Antes de retirar-se definitivamente da sala, devolva ao Fiscal este Caderno. Assinatura do Candidato: UFRN Exame de Proficiência 2017_2 Inglês

2 As questões de 01 a 05, cujas respostas deverão ser redigidas EM PORTUGUÊS, referem-se ao texto abaixo. Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review Leri Septiani, Yudi Mulyana Hidayat, Mutakin, Rizky Abdulah, Ahmad Faried, Hiroshi Koyama Introduction Cervical cancer is the second most common cancer in women worldwide. It is a preventable and a curable disease when identified at an early stage. It is widely accepted that specific human papillomaviruses (HPV) are the central etiologic agents of cervical carcinogenesis. However, there are also other environmental and host factors that play decisive roles in the persistence of HPV infection as well as further malignant conversion of cervical epithelium. It is well known that reactive oxygen species (ROS) play important roles in many pathological conditions including cancer. Under normal conditions their harmful effects upon the cells are neutralized to a large extent by cascades of antioxidant defense mechanisms. Over generation of ROS causes malfunction of antioxidant balance, and it is considered to be in a state of oxidative stress. During cancer development the generation of ROS interferes with organ functions directly by damaging proteins, fats and nucleotides. Selenium is one of the main components of antioxidative mechanisms with evidence that this essential trace element has anticancer properties. The increasing body of evidence suggests the protective role of selenium in several cancers including cervical cancer. Selenium exerts its chemopreventive effect in several ways, such as a defense against oxidative damage by scavenging the ROS, as well as improving the synthesis of enzymatic antioxidant glutathione peroxidase (GPx). The major physiological role of GPx is to maintain appropriate low levels of hydrogen peroxide within the cells and decrease the potential damages due to free radicals. It also provides a second line of defense against hydrogen peroxide that may create damage to membranes and deoxyribonucleate acid (DNA). It was also suggested that low serum selenium levels are linked to miscarriage; hence, selenium seems to play an important role in pregnancy maintenance. GPx activities and low serum concentrations of selenium have been linked to increased risk of many types of cancer including prostate, lung, colorectal, and bladder. However, the role of selenium in preventing carcinogenesis of the cervical is still unclear. No study has explained the roles of selenium in cervical cancer. This study aimed to analyze the serum selenium concentrations and GPx activities in cervical cancer patients compared to the control group, as a preliminary study to explore the role of selenium in cervical cancer. Methods This case-control study included 20 subjects with cervical cancer and 20 healthy subjects. During the sample-processing, measurement of GPx activities in one sample failed. The subjects were women who were newly diagnosed with cervical cancer based on the clinical and histopathological findings, recruited consecutively from patients visited the gynecology outpatient clinic of Dr. Hasan Sadikin General Hospital from May to June The control group included matched healthy women without any malignancy and metabolic disorders, such as heart disease, kidney disorders, hypertension, or diabetes mellitus, based on the socioeconomical factors. Attention should be drawn to the several limitations of this study, including: (I) small patients sample size; (II) potential involvement of other microenvironment signaling pathways in the development of malignancy in cervical cancer; (III) indeed, we cannot fully explain the mechanism of selenium in clinical phenomena. The phenomena of low selenium concentration in cervical cancer patients, in this study, might be related to the complex mechanism, such as metabolism of cancer cell itself, that remains to be elucidated. Understanding of selenium role both in normal and cancer cells might improve therapeutic strategies for patients with malignant diseases. Disponível em:< Journal of Integrated Health Sciences. 2016;4(2) 56-61). Acesso em: 29 jun [Adaptado]. UFRN Exame de Proficiência 2017_2 Inglês Ciências da Saúde 1

3 Questão 1 Segundo o texto, explique quais são os agentes etiológicos comumente associados ao câncer colo-uterino e como eles podem ser afetados por fatores ambientais. Questão 2 De que forma o selênio pode atuar como protetivo nos casos de câncer e especificamente do câncer colo-uterino? UFRN Exame de Proficiência 2017_2 Inglês Ciências da Saúde 2

4 Questão 3 Descreva o objetivo do estudo reportado no texto e explique no que consiste sua relevância, segundo os autores. Questão 4 Discorra sobre os limites do estudo em questão, segundo os autores. UFRN Exame de Proficiência 2017_2 Inglês Ciências da Saúde 3

5 Questão 5 Traduza o fragmento textual abaixo no espaço reservado para isso. Seu texto deverá apresentar clareza e estar bem articulado tanto em termos estruturais quanto de sentido. The major physiological role of GPx is to maintain appropriate low levels of hydrogen peroxide within the cells and decrease the potential damages due to free radicals. It also provides a second line of defense against hydrogen peroxide that may create damage to membranes and deoxyribonucleate acid (DNA). It was also suggested that low serum selenium levels are linked to miscarriage; hence, selenium seems to play an important role in pregnancy maintenance. ESPAÇO DESTINADO AO TEXTO DEFINITIVO UFRN Exame de Proficiência 2017_2 Inglês Ciências da Saúde 4