III INTERNATIONAL SYMPOSIUM OF THE RENIN ANGIOTENSIN SYSTEM (RAS): UNDERSTANDING SYSTEMIC, INTRACELLULAR AND TISSUE RAS

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1 1 III INTERNATIONAL SYMPOSIUM OF THE RENIN ANGIOTENSIN SYSTEM (RAS): UNDERSTANDING SYSTEMIC, INTRACELLULAR AND TISSUE RAS III SIMPÓSIO INTERNACIONAL DO SISTEMA RENINA ANGIOTENSINA (SRA): ENTENDENDO O SRA SISTÊMICO, INTRACELULAR E TECIDUAL 8, 9 e 10 de Agosto de 2014 ENDEREÇO (ADDRESS): Green Place Flat, Rua Dr. Diogo de Faria, 1201, Vila Mariana,São Paulo,SP, Cep: Conferência: Sala Ibirapuera Posters: Sala Trianon INSCRIÇÃO para inscrição: nefrologia@nefro.epm.br Telefone secretaria: , e Valores: R$100,00 (Alunos) e R$250,00 (Professores, Pesquisadores e Profissionais) (pagamentos na secretaria ou no local do evento) COORDINATOR: Dulce Elena Casarini, PhD, FAHA, Department of Medicine, Discipline of Nephrology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil. ORGANIZING COMMITTEE (Comitê organizador): Lisete Michelini, PhD, Departament of Physiology, ICB, USP, São Paulo, Brasil Maria Claudia Irigoyen, MD, PhD, Laboratory of Experimental Hypertension, INCOR, São Paulo, Brasil. Minolfa C. Prieto, MD, PhD. Tulane University, School of Medicine, Department of Physiology, New Orleans, LA, USA L. Gabriel Navar, PhD. Tulane University, School of Medicine, Department of Physiology, New Orleans, LA, USA. SCIENTIFIC COMMITTEE (Comitê cientifico): Mirian Aparecida Boim PhD, Unifesp, Campus Sao Paulo Adriana K Carmona PhD, Unifesp, Campus Sao Paulo Guiomar N. Gomes PhD, Unifesp, Campus Sao Paulo Fernanda Colombo MD, PhD, Incor Fernanda Klein Marcondes PhD, FOP Vera Faha PhD, Mackenzie Tatiana Souza Cunha PhD, Unifesp Campus Diadema Danielle Aragão PhD Unifesp, Campus Sao Paulo Fernanda Aparecida Ronchi PhD, Unifesp, Campus Sao Paulo Juliana Alamada Colucci PhD, Unifesp, Campus Sao Paulo Juliana Dinéia Perez Brandão PhD, Unifesp, Campus Sao Paulo Danielle Yuri Arita PhD, Unifesp, Campus Sao Paulo Ingrid Watanabe PhD, Unifesp, Campus Sao Paulo

2 2 PROGRAM Days: 8, 9 e 10 de agosto de 2014 Sponsors: Universidade Federal de São Paulo, Sociedade Brasileira de Hipertensão, Fundação Oswaldo Ramos, Fapesp, CNPq. August 8 th (8h30 to 17h30) Opening: 8h30 Dulce E. Casarini, PhD. Nephrology Division, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil. L. Gabriel Navar, PhD. Department of Physiology, School of Medicine Tulane University, New Orleans, LA, USA. SYSTEMIC, TISSUE AND LOCAL RAS 8h35-9h00: Gabriel Navar, PhD. Tulane University, School of Medicine, Department of Physiology, New Orleans, LA-USA. Activation of the tubular Renin-Angiotensin System in hypertension 9h05-9h30: Joe Zhuo, PhD. University of Mississippi, Jackson, MS-USA. Current insights and new perspectives on the roles of local paracrine and intracrine renin-angiotensin systems in the kidney 9h35-10h00: Janos Peti-Peterdi, MD. University of South California-USA. A new look of the RAS in the collecting duct 10h00-10h20: coffee break 10h30-11h00: Kumar Rajesh, PhD. Texas A&M Health Science Center. Mechanism of the Renin-Angiotensin System Activation in Diabetes 11h05-11h30: Carlos M Ferrario, MD. Professor, Physiology/Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC Importance of Ang II-forming Non-canonical Pathways in the Human Heart 11h35 13h00 - POSTER SECTION Lunch Break

3 3 14h00-14h25: Mirian Aparecida Boim, PhD. Nephrology Division, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil Mesenchymal stem cells and renovascular hypertension 14h30 14h55: Mark Chappel, PhD. Wake Forest University, NC-USA. Advanced glycation end products (AGEs) and the Angiotensin-(1-7)-Mas Axis 15h00 15h25: João Bosco Pesquero, PhD. Departamento de Biofísica, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil. Normotensive ob/ob mice present high blood aminopeptidase A activity that can be regulated by body weight 15h30-16h00 Cooffe break 16h05-16h30: Romer Gonzalez-Villalobos, MD., PhD. DSRD SAfety Pharmacology- Physiology Group, Pfizer, USA. The renal ACE/Ang II pathway and hypertension 16h35 17h05: Dulce Elena Casarini, PhD. Departamento de Medicina, disciplina de Nefrologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil. Increased ACE gene dosage reduces ACE2 activity in diabetic mice kidney: involvement of ACE/ACE2 balance on the development of diabetic nephropathy August 9 th (8h30 to 17h30) Mirian Aparecida Boim, PhD (confirmed) Nephrology Division, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil. Minolfa C. Prieto, MD, PhD. (confirmed) Tulane University, School of Medicine, Department of Physiology, New Orleans, LA, USA. MOVING FORWARD WITH PRORENIN, RENIN, AND THEIR RECEPTOR 8h35-9h00: Genevieve Nguyen, MD. INSERM, Paris, France,Europe. The (Pro)Renin Receptor Functions 9h05-9h30: Helmy Siragy, Ph.D. University of Virginia. Charlottesville, NC-USA. Regulation of Renal (Pro)renin Receptor Expression by Low Salt Intake

4 4 9h35-10h00: Alexis Gonzalez, PhD. University of Valparaiso, Valparaiso-CHILE. Regulation of renin expression in collecting duct cells 10h00-10h20: coffee break 10h30-11h00: Minolfa C. Prieto, MD, PhD. Department of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA. Closing Remarks in Renin and Pro-renin Receptor 11h05-11h30: Robson Santos, PhD. Departamento de Biofísica e Fisiologia Universidade Federal de Minas Gerais Alamandine, new peptide of RAS Lunch Break Fernanda Klein Marcondes, PhD. Faculdade de Odontologia, Unicamp, Piracicaba, SP, Brazil. Dulce E. Casarini, PhD Nephrology Division, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil. DIABETES and SRA 14h00-14h25: Khalid Elased, PhD. Department of Pharmacology and Toxicology, Wright State University School of Medicine, Dayton, USA Rosiglitazone and Insulin Treatment Downregulate Renal ADAM17 Protein Expression and Attenuate Urinary ACE2 Shedding in Diabetic Mice 14h30 14h55: Eric Lazartigues, Associate Professor of Pharmacology, Health Sciences Center, School of Medicine, New Orleans, LA, USA. Angiotensin-II mediates ACE2 Internalization and Degradation through an Angiotensin-II type I receptor-dependent mechanism 15h00 15h30: Qian Chen Yong, PhD. Texas A&M Health Science Center. Hydrogen sulfide inhibits the activation of the renin-angiotensin system in diabetic heart 15h35 16h00: Candice M Thomas, PhD, Texas A&M Health Science Center. Cardiac-specific genetic inhibition of NF-κB prevents development of diabetic cardiomyopathy

5 5 August 10 th (9h00 to 12h00) Chairs Fernanda Klein Marcondes, PhD. Faculdade de Odontologia, Unicamp, Piracicaba, SP, Brazil. Maria Claudia Irigoyen, MD, PhD. Laboratory of Experimental Hypertension, INCOR, Sao Paulo, Brazil. EXERCISE/ VASCULAR PATHOLOGY / STRESS and KIDNEY DISEASE 9h00 9h30: Carlos Eduardo Negrão, PhD. Faculdade de Educação Física, Universidade de São Paulo, São Paulo, SP, Brazil. Effects of Exercise Training on Circulating and Skeletal Muscle RAS 9h35-10h05: Lisete Michelini, PhD. ICB, Departament of Physiology, Universidade Estadual de Sao Paulo, São Paulo, SP, Brazil. Baroreceptors activity mediates training-induced changes on renin-angiotensin system (RAS) expression within the paraventricular nucleus of the hypothalamus (PVN) 10:10 10h35: Tomasz J. Guzik, MD, PhD. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom. NADPH oxidase, renin angiotensin aldosterone system and vascular pathology 10h40 11h10: Fernanda Klein Marcondes, PhD. Faculdade de Odontologia, Unicamp, Piracicaba, SP, Brazil. RAS and stress. 11h15 11h45: Nadja Grobe, PhD. Wright State University Boonshoft School of Medicine, Department of Pharmacology and Toxicology, Dayton, OH, USA. Maldi imaging of prolyl carboxypeptidase in chronic kidney disease. 11h50 End: Dulce E. Casarini, PhD Nephrology Division, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil.