Lisboa Torres Vedras, 30 de Novembro de 1968

Transcrição

1 Curriculum Vitae Joaquim José Coutinho Ferreira Laboratório de Farmacologia Clínica e Terapêutica Faculdade de Medicina Universidade de Lisboa Av. Prof. Egas Moniz Local e data de nascimento: Lisboa Torres Vedras, 30 de Novembro de 1968 Portugal Casado, 6 filhos jferreira@medicina.ulisboa.pt Nacionalidade: Portuguesa Cargos atuais Presidente, Secção Europeia da Internacional Parkinson and Movement Disorder Society (MDS) Diretor Clínico, CNS Campus Neurológico Sénior, Torres Vedras Grou Leader, Unidade de Farmacologia Clínica (Joaquim Ferreira Lab), Instituto de Medicina Molecular (IMM) Diretor do Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina, Universidade de Lisboa (FMUL) Professor Associado Convidado de Farmacologia Clínica e Neurologia, FMUL Assistente Hospitalar de Neurologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte Educação 2015 Consultor de Neurologia da Carreira Médica Hospitalar pela Ordem dos Médicos 2009 Doutoramento em Medicina (Neurologia) pela FMUL ( Anti-Parkinsonian drugs and sleep disorders in Parkinson s Disease ); orientadores: Prof. Doutora Cristina Sampaio e Prof. Doutor Olivier Rascol (aprovado com distinção e louvor) 2008 Especialista em Farmacologia Clínica pela Ordem dos Médicos 2001 Especialista em Neurologia pelo Hospital de Santa Maria (HSM), com a classificação final de 19,7 valores Estágio de Farmacologia Clínica, Departamento de Farmacologia Clínica e Neurociências, Universidade Paul Sabatier, Toulouse, França (Orientador: Prof. Doutor Olivier Rascol) 1992 Licenciatura em Medicina pela FMUL (1992), com a média final de 17 valores (bom com distinção) 1986 Admissão no Curso de Medicina da FMUL, com a média de candidatura de 19,8 valores º ano na Escola Secundária n.º 2 de Torres Vedras, com a média final de 20 valores Cargos e atividades académicas Professor Associado Convidado de Farmacologia Clínica e Neurologia da FMUL a 100% Regente das Disciplinas de Farmacologia Clínica da FMUL Diretor do Laboratório de Farmacologia Clínica e Terapêutica, FMUL Professor Auxiliar Convidado de Farmacologia Clínica e Neurologia da FMUL a 30% Responsável pelo módulo Therapeutic Research in Neurosciences do Programa de Mestrado/Doutoramento em Neurociências da FMUL Docente convidado do módulo de Doenças Neurodegenerativas do Programa Doutoral para Médicos da Gulbenkian Docente convidado da Cadeira de Neurologia da Licenciatura em Nutrição, FMUL

2 Assistente de Terapêutica Geral e Neurologia da FMUL com dupla titulação (afecto à Cadeira de Terapêutica Geral) Docente convidado da cadeira de Formação Complementar (6º ano), FMUL Docente convidado dos Mestrados de Neurociências, Medicina do Sono, Educação Médica e Cuidados Paliativos da FMUL Responsável pela cadeira de Neurologia do Curso Superior de Terapêutica da Fala (Escola Superior de Saúde de Alcoitão) Responsável pela cadeira de Neurofisiologia do Curso Superior de Terapêutica Ocupacional (Escola Superior de Saúde de Alcoitão) Assistente convidado de Terapêutica Geral, FMUL Assistente Livre de Terapêutica Geral, FMUL Monitor de Anatomia II, FMUL Atividade assistencial Diretor Clínico, CNS Campus Neurológico Sénior, Torres Vedras Assistente Hospitalar de Neurologia, Serviço de Neurologia, Hospital de Santa Maria (HSM), Lisboa Assistente Hospitalar de Neurologia, Serviço de Neurologia, Hospital Rainha Santa Isabel, Torres Novas Assistente Eventual de Neurologia, Serviço de Neurologia, Hospital de São José, Lisboa 2001 Assistente Eventual de Neurologia, Serviço de Neurologia, HSM Coordenador dos tratamentos com toxina botulínica, Serviço de Neurologia, HSM Interno do Internato Complementar de Neurologia, Serviço de Neurologia, HSM Interno do Internato Geral, HSM Membro do Grupo de Doenças do Movimento, Serviço de Neurologia, HSM Atividade de investigação Grou Leader, Unidade de Farmacologia Clínica (Joaquim Ferreira Lab), IMM Investigador Principal, Unidade Neurológica de Investigação Clínica, IMM Investigador, Unidade Neurológica de Investigação Clínica, IMM Estagiário, Laboratório de Farmacologia Médica e Clínica e Centro de Investigação Clínica, Toulouse, França Investigador, Centro de Neurociências de Lisboa Cargos em Sociedades Científicas Nacionais Presidente da Sociedade Portuguesa de Doenças do Movimento Representante da Sociedade Portuguesa de Neurologia (SPN) no European Board of Neurological of European Union of Medical Specialists (UEMS/EBN) Membro do Colégio de Farmacologia Clínica da Ordem dos Médicos Responsável pelo Grupo de Trabalho da SPN sobre Creditação Vice-presidente da Secção de Doenças do Movimento da SPN Membro da Comissão de Ensino da SPN Secretário da Secção de Doenças do Movimento da SPN Assessor da Comissão de Jovens da Sociedade Portuguesa de Neurologia (SPN) Cargos em Sociedades Científicas Internacionais Membro do Comité Executivo da European Academy of Neurology (EAN)

3 Presidente, Secção Europeia da International Parkinson and Movement Disorder Society (MDS) Responsável da Task Force de revisão terapêutica da Doença de Huntington da MDS Presidente-eleito, Secção Europeia da MDS Responsável pelo Comité de Educação da MDS Corresponsável pelo Comité de Membros e Relações Públicas da MDS Membro da Tasque Force de tremor (responsável do working group de revisão terapêutica) da MDS Responsável pelo Sub-comité de Educação da Secção Europeia da MDS Membro do Web Site Editorial Board da MDS Membro do Comité Executivo da Secção Europeia da MDS Membro do Grupo de Trabalho da Website da MDS Membro do Comité de Relações Públicas e Ligação da MDS 2003 Membro do Comité de Educação da MDS Secretário do painel de Neurofarmacologia da European Federation of Neurological Societies (EFNS) Vice-presidente da European Association for Young Neurologists and Neurology Trainees (YNT) Membro do Steering Committee of Trainees and Junior Neurologists da EFNS Outras atividades em Instituições/Organizações Nacionais Membro do Comité Científico da Associação Portuguesa de Doentes de Parkinson Consultor da Unidade de Farmacovigilância de Lisboa e Vale do Tejo, FMUL Membro do Centro de Medicina Baseada na Evidencia, FMUL Outras atividades em Instituições/Organizações Internacionais Corresponsável do Clinical Working Partie, COST Action BM1101 European network for the study of dystonia syndromes Membro do Clinical Trials Taskforce, European Huntington Disease Network (EHDN) Diretor Científico, Europeia Huntington Disease Network (EHDN) Responsável do The Neuroprotectice Therapy Working Group, EHDN 2008 Membro do Comité Executivo da EHDN Membro do Scientific and Bioethics Advisory Committee da EHDN Atividades de direção/coordenação Presidente, Secção Europeia da International Parkinson and Movement Disorder Society (MDS) Diretor Clínico, CNS Campus Neurológico Sénior, Torres Vedras Group Leader, Instituto de Medicina Molecular Presidente da Sociedade Portuguesa de Doenças do Movimento Regente das Disciplinas de Farmacologia Clínica da FMUL Diretor do Laboratório de Farmacologia Clínica e Terapêutica, FMUL Diretor Científico, European Huntington Disease Network Responsável pelo Comité de Relações Públicas e Ligação da MDS Responsável pelo Subcomité de Educação da Secção Europeia da MDS Coordenador da Unidade de Ensaios Clínicos do Serviço de Neurologia, HSM, CHLN

4 Coordenador do Cochrane Movimente Disorders Review Group da Cochrane Collaboration Projetos de investigação financiados Projeto financiado pela JPND: COURAGE-PD COmprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson s Disease (IMM ) Projeto financiado pela JPND: Clãs: Care for Late Stage Parkinsonism (IMM ) Projeto financiado pela FCT: Imagina of Basal Ganglia from Magnetic Induction Tomography Projeto financiado pela FCT: Glucocerebrosidase in Parkinson's disease: from risk factor to biomarker Projeto financiado pela FP7: SENSE-PARK ( ): Sporting and Empowering Parkinson patients in their home environment using a Novel Sensory information system that monitors daily life-relevant parameters of Parkinson disease and their change. (IMM ,00) Projeto financiado pela APDP e DRS: Epidemiológica study to assess the prevalence of Parkinson's disease in Portugal, , Projeto financiado pela FCT: Show and Rapid Progression Parkinson s Disease: Molecular Determinants and Biomarkers, Foundation for Science and Technology. Investigador principal: Tiago Outeiro. PIC/IC/82760/2007, , Projeto financiado pela FCT: MicroRnómica and proteomics of Parkinson's disease." Study conducted in collaboration with the Gulbenkian Institute of Science. PTDC/SAU-GMG/64428/2006, ,00 Investigador Responsável WP Systematic review Investigador Investigador Responsável pelo work package 7: scenario-based multicenter study Investigador principal Investigador Investigador Atividade editorial/revisor Editor associado dos jornais Fronteiras in Movement Disorders e Acta Reumatológica Portuguesa ( ) Membro do Comité Editorial dos jornais: Journal of Parkinson s Disease, Journal of Huntington s Disease, PLOS Currents Huntington Disease Revisor convidado dos jornais: CNS Neuroscience and Therapeutics, European Journal of Neurology, Movement Disorders Journal, Expert Review of Neurotherapeutics, Expert Opinion on Drug Safety, Aging Health, The Journal of Pain, Journal of Neurology, Neuroscience Letters, Sinapse, Journal of Neurology Neurosurgery and Psychiatry, Journal of Medical Ethics, Journal of Neural Transmission, The European Neurological Journal, Dovepress, Expert Opinion On Drug Metabolism and Toxicology, Parkinsonism and Related Disorders Revisor convidado de candidaturas para financiamento submetidas ao Parkinson s Disease Society, UK ( ); Action Medical Research, UK (2007); Gabinete de Apoio à Investigação Científica (GAPIC), FMUL Revisor convidado do 2012 NEURON joint transnational call Novel Methods and Approaches towards the Understanding of Brain Diseases Orientação de formação e teses de mestrado/doutoramento Orientador de formação de 3 internos de neurologia (2 concluídos) Orientador de 10 teses do Mestrado Integrado em Medicina da FMUL Orientador de 2 dissertações de mestrado em neurociências apresentadas à FMUL e 3 em curso

5 Orientador de 2 dissertações de mestrado apresentadas à Universidade Católica Portuguesa Orientador de uma tese de doutoramento apresentada à FMUL (concluída) e seis dissertações em curso na FMUL Áreas de interesse preferencial Farmacologia Clínica, Neurofarmaclogia, Doenças do Movimento, Doença de Parkinson, Doença de Huntington, Toxina Botulínica, Ensaios Clínicos, Revisões Sistemáticas Publicações em revistas indexadas (h-índex 38; nº citações 5332) 1. Rui Araújo, Joaquim J Ferreira, Angelo Antonini, Bastiaan R Bloem: "Gunslinger's gait": a new cause of unilaterally reduced arm swing. BMJ (online) 12/2015; 351:h6141. DOI: /bmj.h Joaquim J Ferreira, Andrew Lees, José-Francisco Rocha, Werner Poewe, Olivier Rascol, Patrício Soares-da-Silva: Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial. The Lancet Neurology 12/2015; DOI: /S (15) Margherita Fabbri, Mario M Rosa, Daisy Abreu, Joaquim J Ferreira: Clinical pharmacology review of safinamide for the treatment of Parkinson s disease. 11/2015; 5(6). DOI: /nmt S Reimão, S Ferreira, R G Nunes, P Pita Lobo, D Neutel, D Abreu, N Gonçalves, J Campos, J J Ferreira: Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson's disease. European Journal of Neurology 10/2015; DOI: /ene Tiago Teodoro, Pedro Viana, Daisy Abreu, Isabel Conceição, Rita Peralta, Joaquim J Ferreira: A peripheral pathway to restless legs syndrome? Clues from familial amyloid polyneuropathy. Parkinsonism & Related Disorders 10/2015; 21. DOI: /j.parkreldis Margherita Fabbri, Giorgio Leodori, Ricardo M Fernandes, Roongroj Bhidayasiri, Maria Jose Marti, Carlo Colosimo, Joaquim J Ferreira: Neutralizing Antibody and Botulinum Toxin Therapy: A Systematic Review and Meta-analysis. Neurotoxicity Research 10/2015; DOI: /s Dulce Neutel, Rita Peralta, Joana Pires, Carla Bentes, Joaquim J. Ferreira: End of OSLER Test Sessions in Parkinson s Disease do not Correspond to True Sleep Onset: Results from an Exploratory Study. Frontiers in Neurology 09/2015; 6. DOI: /fneur Josefa M Domingos, Catarina Godinho, John Dean, Miguel Coelho Md, Anabela Pinto, Bastiaan R Bloem, Joaquim J Ferreira: Cognitive Impairment in Fall-Related Studies in Parkinson Disease. Journal of Parkinson's Disease 09/2015; 5(3): DOI: /JPD Sofia Reimão, Patricia Pita Lobo, Dulce Neutel, Leonor Correia Guedes, Miguel Coelho, Mario M. Rosa, Joana Ferreira, Daisy Abreu, Nilza Gonçalves, Carlos Morgado, Rita G. Nunes, Jorge Campos, Joaquim J. Ferreira: Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson s disease. Journal of Parkinson's Disease 09/2015; 5(3): DOI: /JPD Daniel Caldeira, Joaquim J Ferreira, João Costa: Glaucoma Surgery and Anticoagulant Therapy-Reply. Jama Ophthalmology 09/2015; DOI: /jamaophthalmol D. Caldeira, M. Barra, A. Ferreira, A. Rocha, A. Augusto, F. J. Pinto, J. Costa, J. J. Ferreira: Systematic review with meta-analysis: The risk of major gastrointestinal bleeding with non-vitamin K antagonist oral anticoagulants. Alimentary Pharmacology & Therapeutics 09/2015; 42(11):n/a-n/a. DOI: /apt Olivier Rascol, Santiago Perez-Lloret, Joaquim J Ferreira: New treatments for levodopa-induced motor complications. Movement Disorders 08/2015; 30(11). DOI: /mds José-Francisco Rocha, Joaquim J. Ferreira, Amílcar Falcão, Ana Santos, Roberto Pinto, Teresa Nunes, Luis Almeida, Patrício Soares-da-Silva: Effect of three single-dose regimens of opicapone on levodopa pharmacokinetics, catechol-o-methyltransferase activity and motor response in patients with Parkinson's disease. Clinical Pharmacology in Drug Development 08/2015; DOI: /cpdd Joaquim J Ferreira, Anne Rosser, David Craufurd, Ferdinando Squitieri, Nicholas Mallard, Bernhard Landwehrmeyer: Ethyl-eicosapentaenoic acid treatment in Huntington's disease: A placebo-controlled clinical trial. Movement Disorders 07/2015; 30(10). DOI: /mds Daniel Caldeira, Nilza Gonçalves, Joaquim J Ferreira, Fausto J Pinto, João Costa: Tolerability and Acceptability of Non-Vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation: Systematic Review and Meta-Analysis. American Journal of Cardiovascular Drugs 06/2015; 15(4). DOI: /s Joaquim J. Ferreira, Catarina Godinho, Ana T. Santos, Josefa Domingos, Daisy Abreu, Raquel Lobo, Nilza Gonçalves, Marcio Barra, Frank Larsen, Øyvind Fagerbakke, Ingvild Akeren, Hilde Wangen, J. Artur Serrano, Peter Weber, Andrea Thoms, Stefan Meckler, Stefan Sollinger, Janet van Uem, Markus A. Hobert, Katrin S. Maier, Helen Matthew, Tom Isaacs, Joy Duffen, Holm Graessner, Walter Maetzler: Quantitative home-based assessment of Parkinson s symptoms: The SENSE-PARK feasibility and usability study. BMC Neurology 06/2015; 15(1). DOI: /s z 17. Inês Tello Rodrigues, Joaquim J Ferreira, Miguel Coelho, Mario Miguel Rosa, Alexandre Castro-Caldas: Action verbal fluency in Parkinson s patients. Arquivos de Neuro-Psiquiatria 06/2015; 73(6). DOI: / X Daniel Caldeira, Filipe B Rodrigues, Márcio Barra, Ana Teresa Santos, Daisy de Abreu, Nilza Gonçalves, Fausto J Pinto, Joaquim J Ferreira, João Costa: Non-Vitamin K antagonist oral anticoagulants and major bleeding-related fatality in patients with atrial fibrillation and venous thromboembolism: A systematic review and meta-analysis. Heart (British Cardiac Society) 06/2015; 101(15): DOI: /heartjnl Tiago Teodoro, Hipólito Nzwalo, Leonor Correia Guedes, Miguel Coelho, Mário M. Rosa, Joaquim J. Ferreira: Suicidal behaviors are very rare in antiparkinsonian drug trials. Parkinsonism & Related Disorders 06/2015; 21(8). DOI: /j.parkreldis Daniel Caldeira, Mário Canastro, Márcio Barra, Adriana Ferreira, João Costa, Fausto J Pinto, Joaquim J Ferreira: Risk of Substantial Intraocular Bleeding With Novel Oral Anticoagulants. Jama Ophthalmology 05/2015; 133(7). DOI: /jamaophthalmol Tiago Teodoro, Patrícia Pita Lobo, João Ferreira, Rita Sousa, Sofia Reimão, Rita Peralta, Luísa Albuquerque, Joaquim J. Ferreira: Delayed Parkinsonism after acute chorea due to non-ketotic hyperglycemia. Journal of the neurological sciences 05/2015; 354(1-2). DOI: /j.jns Joana Morgado, Sofia Reimão, Miguel Coelho, Mário M. Rosa, Joaquim J. Ferreira, Leonor Correia Guedes: Eye of the Tiger Sign and Very Late Onset in Dentatorubral-Pallidoluysian Atrophy. 05/2015; 2(3). DOI: /mdc Daniel Caldeira, Nilza Gonçalves, Fausto J. Pinto, João Costa, Joaquim J. Ferreira: Risk of renal failure with the non-vitamin K antagonist oral anticoagulants: systematic review and meta-analysis: NOACs and Incidence of Renal Failure. Pharmacoepidemiology and Drug Safety 05/2015; 24(7). DOI: /pds.3791

6 24. Sofia Reimão, Patricia Pita Lobo, Dulce Neutel, Leonor Correia Guedes, Miguel Coelho, Mário M Rosa, Pedro Azevedo, Joana Ferreira, Daisy Abreu, Nilza Gonçalves, Rita G Nunes, Jorge Campos, Joaquim J Ferreira: Substantia nigra neuromelanin-mr imaging differentiates essential tremor from Parkinson's disease. Movement Disorders 03/2015; 30(7). DOI: /mds Joaquim J Ferreira, Ana T Santos, Josefa Domingos, Helen Matthews, Tom Isaacs, Joy Duffen, Ahmed Al-Jawad, Frank Larsen, Artur Serrano, Peter Weber, Andrea Thoms, Stefan Sollinger, Holm Graessner, Walter Maetzler: Clinical Parameters and Tools for Home-Based Assessment of Parkinson s Disease: Results from a Delphi study. Journal of Parkinson's Disease 02/2015; 5(2). DOI: /JPD Daniel Caldeira, João Costa, Joaquim J Ferreira, Gregory Y H Lip, Fausto J Pinto: Non-vitamin K antagonist oral anticoagulants in the cardioversion of patients with atrial fibrillation: systematic review and meta-analysis. Clinical Research in Cardiology 02/2015; 104(7). DOI: /s Joaquim J. Ferreira, José-Francisco Rocha, Amílcar Falcão, Ana Santos, Roberto Pinto, Teresa Nunes, Patrício Soares-da-Silva: Effect of opicapone on levodopa pharmacokinetics, catechol-o-methyltransferase activity and motor fluctuations in patients with Parkinson's disease. European Journal of Neurology 02/2015; 22(5). DOI: /ene Daniel Caldeira, Márcio Barra, Ana Teresa Santos, Daisy de Abreu, João Costa, Joaquim J Ferreira: Risk of insomnia with non-vitamin K oral anticoagulants: systematic review and meta-analysis. Sleep And Breathing 01/2015; 19(3). DOI: /s J Artur Serrano, Frank Larsen, Tom Isaacs, Helen Matthews, Joy Duffen, Sara Riggare, Fulvio Capitanio, Joaquim J. Ferreira, Josefa Domingos, Walter Maetzler, Holm Graessner: Participatory Design in Parkinson's Research with Focus on the Symptomatic Domains to be Measured. Journal of Parkinson's Disease 01/2015; 5(1). DOI: /JPD Daniel Caldeira, Márcio Barra, Nilza Gonçalves, Fausto J Pinto, Joaquim J Ferreira, João Costa: Pericardial bleeding risk with non-vitamin K oral anticoagulants: A meta-analysis. International Journal of Cardiology 12/2014; 182C: DOI: /j.ijcard S. Reimão, P. Pita Lobo, D. Neutel, L. Correia Guedes, M. Coelho, M. M. Rosa, J. Ferreira, D. Abreu, N. Gonçalves, C. Morgado, R. G. Nunes, J. Campos, J. J. Ferreira: Substantia nigra neuromelanin magnetic resonance imaging in de novo Parkinson's disease patients. European Journal of Neurology 12/2014; 22(3). DOI: /ene Joaquim J. Ferreira, Carlo Colosimo, Roongroj Bhidayasiri, Maria Jose Marti, Pascal Maisonobe, Om Savary: Factors influencing secondary nonresponse to botulinum toxin type A injections in cervical dystonia. Parkinsonism & Related Disorders 11/2014; 21(2). DOI: /j.parkreldis Daniel Caldeira, João Costa, Joaquim J. Ferreira, Fausto J. Pinto: Thromboembolic risk in the initiation, switch and interruption/re-initiation of oral anticoagulants: Do newcomers improve outcomes? Insights from a meta-analysis of RCTs. International Journal of Cardiology 11/2014; 177(1): DOI: /j.ijcard Daniel Caldeira, João Costa, Márcio Barra, Fausto J. Pinto, Joaquim J. Ferreira: How safe is acetaminophen use in patients treated with vitamin K antagonists? A systematic review and meta-analysis. Thrombosis Research 10/2014; 135(1). DOI: /j.thromres Marialuisa Quadri, Xu Yang, Giovanni Cossu, Simone Olgiati, Valeria M Saddi, Guido J Breedveld, Limei Ouyang, Jingchu Hu, Na Xu, Josja Graafland, Valeria Ricchi, Daniela Murgia, Leonor Correia Guedes, Claudio Mariani, Maria J Marti, Patrizia Tarantino, Rosanna Asselta, Francesc Valldeoriola, Monica Gagliardi, Gianni Pezzoli, Mario Ezquerra, Aldo Quattrone, Joaquim Ferreira, Grazia Annesi, Stefano Goldwurm, Eduardo Tolosa, Ben A Oostra, Maurizio Melis, Jun Wang, Vincenzo Bonifati: An exome study of Parkinson s disease in Sardinia, a Mediterranean genetic isolate. Neurogenetics 10/2014; 16(1). DOI: /s x 36. Daniel Caldeira, Márcio Barra, Cláudio David, João Costa, Joaquim J Ferreira, Fausto J Pinto: The prevalence of oral anticoagulation in patients with atrial fibrillation in Portugal: Systematic review and meta-analysis of observational studies. 09/2014; 33(9). DOI: /j.repce Marcus Munafò, Simon Noble, William J Browne, Dani Brunner, Katherine Button, Joaquim Ferreira, Peter Holmans, Douglas Langbehn, Glyn Lewis, Martin Lindquist, Kate Tilling, Eric-Jan Wagenmakers, Robi Blumenstein: Scientific rigor and the art of motorcycle maintenance. Nature Biotechnology 09/2014; 32(9): DOI: /nbt N. Goncalves, J. J. Ferreira, D. de Abreu, L. Correia-Guedes, J. Giuliano, C. Fitzer-Attas, C. Sampaio: J23 Evaluation of Validity of UHDRS Translations in the Registry Study. Journal of Neurology Neurosurgery & Psychiatry 09/2014; 85(Suppl 1):A73-A73. DOI: /jnnp Daniel Caldeira, Márcio Barra, Cláudio David, João Costa, Joaquim J. Ferreira, Fausto J. Pinto: Prevalência da anticoagulação oral em doentes com fibrilhação auricular em Portugal: revisão sistemática e meta-análise de estudos observacionais. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 09/2014; 33(9). DOI: /j.repc M. Coelho, M. J. Marti, C. Sampaio, J. J. Ferreira, F. Valldeoriola, M. M. Rosa, E. Tolosa: Dementia and severity of parkinsonism determines the handicap of patients in late-stage Parkinson's disease: The Barcelona-Lisbon cohort. European Journal of Neurology 09/2014; 22(2). DOI: /ene Daniel Caldeira, Márcio Barra, Fausto J Pinto, Joaquim J Ferreira, João Costa: Intracranial hemorrhage risk with the new oral anticoagulants: A systematic review and meta-analysis. Journal of Neurology 08/2014; 262(3). DOI: /s Daniel Caldeira, Maria José Loureiro, João Costa, Fausto J. Pinto, Joaquim J. Ferreira: Oral Anticoagulation for Pulmonary Arterial Hypertension: Systematic Review and Meta-analysis. The Canadian journal of cardiology 08/2014; 30(8). DOI: /j.cjca Walter Maetzler, Marie Karam, Monika Fruhmann Berger, Tanja Heger, Corina Maetzler, Heinz Ruediger, Juliana Bronzova, Patricia Pita Lobo, Joaquim J Ferreira, Tjalf Ziemssen, Daniela Berg: Time- and frequency-domain parameters of heart rate variability and sympathetic skin response in Parkinson s disease. Journal of Neural Transmission 07/2014; 122(3). DOI: /s Daniel Caldeira, João Costa, Ricardo M Fernandes, Fausto J Pinto, Joaquim J Ferreira: Performance of the HAS-BLED high bleeding-risk category, compared to ATRIA and HEMORR2HAGES in patients with atrial fibrillation: a systematic review and meta-analysis. Journal of Interventional Cardiac Electrophysiology 07/2014; DOI: /s y 45. Tiago A. Mestre, Tiago Teodoro, William Reginold, Julia Graf, Maike Kasten, Joanna Sale, Mateusz Zurowski, Janis Miyasaki, Joaquim J. Ferreira, Connie Marras: Reluctance to start medication for Parkinson s disease: A mutual misunderstanding by patients and physicians. Parkinsonism & Related Disorders 06/2014; 20(6). DOI: /j.parkreldis Daniel Caldeira, João Costa, Joaquim J Ferreira, Fausto J Pinto: Net clinical benefit outcome should be standardized in trials evaluating antithrombotic drugs: The example of NOACs in atrial fibrillation. International journal of cardiology 04/2014; 174(2). DOI: /j.ijcard Daniel Caldeira, Fausto J Pinto, Joaquim J Ferreira: Dyspnea and Reversibility Profile of P2Y12 Antagonists: Systematic Review of New Antiplatelet Drugs. American Journal of Cardiovascular Drugs 03/2014; 14(4). DOI: /s M. Fabbri, L.C. Guedes, M. Coelho, D. Simão, D. Abreu, M.M. Rosa, L. Silveira-Moriyama, J.J. Ferreira: Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease. European Journal of Neurology 03/2014; 22(1). DOI: /ene.12396

7 49. Daniel Caldeira, Cláudio David, Ana T. Santos, João Costa, Fausto J. Pinto, Joaquim J. Ferreira: Efficacy and safety of low molecular weight heparin in patients with mechanical heart valves: Systematic review and meta-analysis. Journal of Thrombosis and Haemostasis 03/2014; 12(5). DOI: /jth Daniel Caldeira, Márcio Barra, Ana Teresa Santos, Daisy de Abreu, Fausto J Pinto, Joaquim J Ferreira, João Costa: Risk of drug-induced liver injury with the new oral anticoagulants: Systematic review and meta-analysis. Heart (British Cardiac Society) 01/2014; 100(7). DOI: /heartjnl Daniel Caldeira, João Costa, Fausto J Pinto, Joaquim J Ferreira: The risk of infection with new oral anticoagulants: A meta-analysis. International journal of cardiology 01/2014; 172(1). DOI: /j.ijcard Josefa Domingos, Miguel Coelho, Joaquim J Ferreira: Referral to rehabilitation in parkinson's disease: Who, when and to what end?. Arquivos de neuro-psiquiatria 12/2013; 71(12): DOI: / X Luisa Albuquerque, Miguel Coelho, Maurício Martins, Leonor Correia Guedes, Mário M Rosa, Joaquim J Ferreira, Maria Begoña Cattoni, Herculano Carvalho, A Gonçalves Ferreira, Isabel Pavão Martins: STN-DBS does not change emotion recognition in advanced Parkinson's disease. Parkinsonism & Related Disorders 10/2013; 20(2). DOI: /j.parkreldis J.J. Ferreira, J.-F. Rocha, A. Falcão, R. Pinto, T. Nunes, P. Soares-da-Silva: Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics, motor response, and erythrocyte-comt activity in Parkinson's patients co-administered with levodopa/dopa-decarboxylase inhibitor. 55. Walter Maetzler, Josefa Domingos, Karin Srulijes, Joaquim J Ferreira, Bastiaan R Bloem: Quantitative Wearable Sensors for Objective Assessment of Parkinson's Disease. Movement Disorders 10/2013; 28(12). DOI: /mds Daniel Caldeira, Cristina Martins, Luís Brandão Alves, Hélder Pereira, Joaquim J Ferreira, João Costa: Caffeine does not increase the risk of atrial fibrillation: A systematic review and meta-analysis of observational studies. Heart (British Cardiac Society) 10/2013; 99(19): DOI: /heartjnl Jörg Wissel, Joaquim J. Ferreira, Djamel Bensmail, Peter Kossmehl, Lourdes López de Munaín, Tiina Rekand, Lalith Satkunam, David Simpson: TOWER: Design of an Open-Label Incobotulinumtoxina Dose-Titration Study ( 800 U) In Lower- and Upper-Limb Spasticity. PM&R 09/2013; 5(9):S142-S143. DOI: /j.pmrj Patricia Pita Lobo, Miguel Coelho, Tiago A Mestre, Mário M Rosa, Joaquim J Ferreira: Wearing-off phenomena and levodopa-induced dyskinesias in posttraumatic hemiparkinsonism. Movement Disorders 08/2013; 28(9). DOI: /mds Daniel Caldeira, Ricardo M Fernandes, Cláudio David, João Costa, Joaquim J Ferreira: Warfarin, acetylsalicylic acid and risk of incident atrial fibrillation in patients with heart failure and sinus rhythm: A meta-analysis. International journal of cardiology 07/2013; 168(5). DOI: /j.ijcard S. Metzger, C. Walter, O. Riess, R. A. Roos, J. E. Nielsen, D. Craufurd, A. C. Bachoud-Lévi, A. R. Bentivoglio, I. Biunno, R. M. Bonelli, J. M. Burgunder, S. B. Dunnett, J. J. Ferreira, O. J. Handley, et al: The V471A Polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients. PLoS ONE 07/2013; 61. Isabel Pavão Martins, Gabriela Leal, Isabel Fonseca, Luísa Farrajota, Marta Aguiar, José Fonseca, Martin Lauterbach, Luís Gonçalves, M Carmo Cary, Joaquim J Ferreira, Jose M Ferro: A randomized, rater-blinded, parallel trial of intensive speech therapy in sub-acute post-stroke aphasia: The SP-I-R-IT study. International Journal of Language & Communication Disorders 07/2013; 48(4): DOI: / Lei Zhang, Marialuisa Quadri, Leonor Correia Guedes, Miguel Coelho, Anabela Valadas, Tiago Mestre, Patrícia Pita Lobo, Mário Miguel Rosa, Erik Simons, Ben A Oostra, Joaquim J Ferreira, Vincenzo Bonifati: Comprehensive LRRK2 and GBA screening in Portuguese patients with Parkinson's disease: Identification of a new family with the LRRK2 p.arg1441his mutation and novel missense variants. Parkinsonism & Related Disorders 05/2013; 19(10). DOI: /j.parkreldis Tiago Teodoro, Dulce Neutel, Patrícia Lobo, Ana F Geraldo, Isabel Conceição, Mário M Rosa, Luísa Albuquerque, Joaquim J Ferreira: Recovery after copper-deficiency myeloneuropathy in Wilson's disease. Journal of Neurology 05/2013; 260(7). DOI: /s W. Maetzler, M. Karam, T. Heger, P. Pita Lobo, J.J. Ferreira, T. Ziemssen, D. Berg: Heart rate variability and sympathetic skin response in Parkinson's disease: Baseline assessment of the MODEP study. Basal Ganglia 03/2013; 3(1): DOI: /j.baga A Berardelli, G K Wenning, A Antonini, D Berg, B R Bloem, V Bonifati, D Brooks, D J Burn, C Colosimo, A Fanciulli, J Ferreira, T Gasser, F Grandas, P Kanovsky, V Kostic, J Kulisevsky, W Oertel, W Poewe, J-P Reese, M Relja, E Ruzicka, A Schrag, K Seppi, P Taba, M Vidailhet: EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease. European Journal of Neurology 01/2013; 20(1): DOI: /ene J J Ferreira, R Katzenschlager, B R Bloem, U Bonuccelli, D Burn, G Deuschl, E Dietrichs, G Fabbrini, A Friedman, P Kanovsky, V Kostic, A Nieuwboer, P Odin, W Poewe, O Rascol, C Sampaio, M Schüpbach, E Tolosa, C Trenkwalder, A Schapira, A Berardelli, W H Oertel: Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson's disease. European Journal of Neurology 01/2013; 20(1):5-15. DOI: /j x 67. Daniel Caldeira, Ricardo M Fernandes, João Costa, Cláudio David, Cristina Sampaio, Joaquim J Ferreira: Branded Versus Generic Clopidogrel in Cardiovascular Diseases: A Systematic Review. Journal of cardiovascular pharmacology 11/2012; 61(4). DOI: /FJC.0b013e31827e5c T. A. Mestre, A. E. Lang, J. J. Ferreira: Associated movement disorders in orthostatic tremor (vol 83, pg 725, 2012). Journal of Neurology Neurosurgery & Psychiatry 11/2012; 83(11): DOI: /jnnp corr1 69. Joaquim J Ferreira, Dulce Neutel, Tiago A Mestre, Monique Galitzky, Claire Thalamas, Ana T Santos, Cristina Sampaio, Olivier Rascol: Usefulness of OSLER test in Parkinson's disease. Sleep Medicine 10/2012; 14(3). DOI: /j.sleep Joaquim J Ferreira, Roongroj Bhidayasiri, Carlo Colosimo, Maria Jose Marti, Benjamin Zakine, Pascal Maisonobe: Survey of practices employed by neurologists for the definition and management of secondary nonresponse to botulinum toxin in cervical dystonia. Functional neurology 10/2012; 27(4): Robert B Chinnapongse, Mark F Lew, Joaquim J Ferreira, Kristen L Gullo, Paul R Nemeth, Yuxin Zhang: Immunogenicity and Long-Term Efficacy of Botulinum Toxin Type B in the Treatment of Cervical Dystonia. Clinical neuropharmacology 08/2012; 35(5): DOI: /WNF.0b013e c 72. Miguel Coelho, Joaquim J Ferreira: Late-stage Parkinson disease. Nature Reviews Neurology 07/2012; 8(8): DOI: /nrneurol Tiago A Mestre, A E Lang, Joaquim J Ferreira, Vânia Almeida, Mamede de Carvalho, Janis Miyasaki, Robert Chen, Susan Fox: Associated movement disorders in orthostatic tremor. Journal of neurology, neurosurgery, and psychiatry 05/2012; 83(7): DOI: /jnnp Susana Margarida Rodrigues, Mamede de Carvalho, Tiago Mestre, Joaquim J Ferreira, Miguel Coelho, Rita Peralta, Paulo Vale: Paralytic shellfish poisoning due to ingestion of Gymnodinium catenatum contaminated cockles - Application of the AOAC HPLC Official Method. Toxicon 04/2012; 59(5): DOI: /j.toxicon T.A. Mestre, J.J. Ferreira: An evidence-based approach in the treatment of Huntington's disease. Parkinsonism & Related Disorders 12/2011; 18(4): DOI: /j.parkreldis

8 76. Christopher G Goetz, Glenn T Stebbins, Ad Theeuwes, Fabrizio Stocchi, Joaquim J Ferreira, Serge van de Witte, Juliana Bronzova: Temporal stability of the Unified Dyskinesia Rating Scale. Movement Disorders 12/2011; 26(14): DOI: /mds Madalena Martins, Alexandra Rosa, Leonor C Guedes, Benedita V Fonseca, Kristina Gotovac, Sara Violante, Tiago Mestre, Miguel Coelho, Mário M Rosa, Eden R Martin, Jeffery M Vance, Tiago F Outeiro, Liyong Wang, Fran Borovecki, Joaquim J Ferreira, Sofia A Oliveira: Convergence of mirna Expression Profiling, α-synuclein Interacton and GWAS in Parkinson's Disease. PLoS ONE 10/2011; 6(10):e DOI: /journal.pone Tiago Teodoro, Daniela Pires, Mário M Rosa, Miguel Coelho, Cristina Sampaio, Joaquim J Ferreira: Has "Levodopa-Induced Neuropathy" Been Reported in Parkinson's Disease Clinical Trials?. Movement Disorders 08/2011; 26(10): DOI: /mds Anabela Valadas, Miguel Coelho, Tiago Mestre, Leonor Correia Guedes, Maria Finisterra, Ana Noronha, Mário M Rosa, Cristina Sampaio, Joaquim J Ferreira: What motivates Parkinson's disease patients to enter clinical trials?. Parkinsonism & Related Disorders 06/2011; 17(9): DOI: /j.parkreldis Olivier Rascol, Joaquim Ferreira, Laurence Nègre-Pages, Santiago Perez-Lloret, Lucette Lacomblez, Monique Galitzky, Jean-Christophe Lemarié, Jean- Christophe Corvol, Jonathan M Brotchie, Laura Bossi: A proof-of-concept, randomized, placebo-controlled, multiple cross-overs (n-of-1) study of naftazone in Parkinson's disease. Fundamental and Clinical Pharmacology 05/2011; 26(4): DOI: /j x 81. S Reimão, C Morgado, L Neto, J Ferreira, M Coelho, M Rosa, J Campos: Diffusion Tensor Imaging in Movement Disorders: Review of Major Patterns and Correlation with Normal Brainstem/cerebellar White Matter. 05/2011; 24(2): DOI: / Birgit Högl, Isabelle Arnulf, Cynthia Comella, Joaquim Ferreira, Alex Iranzo, Barbara Tilley, Claudia Trenkwalder, Werner Poewe, Olivier Rascol, Cristina Sampaio, Glenn T Stebbins, Anette Schrag, Christopher G Goetz: Scales to Assess Sleep Impairment in Parkinson's Disease: Critique and Recommendations. Movement Disorders 12/2010; 25(16): DOI: /mds Joaquim J Ferreira, Olivier Rascol, Werner Poewe, Cristina Sampaio, José-Francisco Rocha, Teresa Nunes, Luis Almeida, Patrício Soares-da-Silva: A Double-Blind, Randomized, Placebo and Active-Controlled Study of Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease. CNS Neuroscience & Therapeutics 12/2010; 16(6): DOI: /j x 84. Cristina Sampaio, Joaquim J Ferreira: Parkinson disease: Adjunctive entacapone therapy increases risk of dyskinesia. Nature Reviews Neurology 11/2010; 6(11): DOI: /nrneurol W.H. Oertel, A. Berardelli, B.R. Bloem, U. Bonuccelli, D. Burn, G. Deuschl, E. Dietrichs, G. Fabbrini, J.J. Ferreira, A. Friedman, P. Kanovsky, V. Kostic, A. Nieuwboer, P. Odin, W. Poewe, O. Rascol, C. Sampaio, M. Schüpbach, E. Tolosa, C. Trenkwalder: Early (Uncomplicated) Parkinson's Disease. 86. M. Coelho, T. Mestre, J. J. Ferreira: LATE-STAGE HUNTINGTON'S DISEASE (HD): A COHORT FROM THE EUROPEAN HD NETWORK. Journal of Neurology Neurosurgery & Psychiatry 09/2010; 81(Suppl 1):A24-A24. DOI: /jnnp Miguel Coelho, Maria J Marti, Eduardo Tolosa, Joaquim J Ferreira, Francesc Valldeoriola, Mário Rosa, Cristina Sampaio: Late-stage Parkinson's disease: The Barcelona and Lisbon cohort. Journal of Neurology 09/2010; 257(9): DOI: /s Mário Miguel Rosa, Joaquim J Ferreira, Miguel Coelho, Rita Freire, Cristina Sampaio: Prescribing Patterns of Antiparkinsonian Agents in Europe. Movement Disorders 06/2010; 25(8): DOI: /mds MSc Elan D. Louis MD, Joaquim J. Ferreira MD, Elan D. Louis, Joaquim J. Ferreira: How Common Is the Most Common Adult Movement Disorder? Update on the Worldwide Prevalence of Essential Tremor. Movement Disorders 04/2010; 25(5): DOI: /mds Tiago Mestre, Joaquim J Ferreira: Pharmacotherapy in Parkinsongs disease: Case studies. Therapeutic Advances in Neurological Disorders 03/2010; 3(2): DOI: / Rodrigo A Salinas, Gonzalo Alvarez, Fergus Daly, Joaquim Ferreira: Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane database of systematic reviews (Online) 03/2010; 3(3):CD DOI: / CD pub4 92. Cristina Sampaio, Joaquim J Ferreira: Parkinson disease: ADAGIO trial hints that rasagiline slows disease progression. Nature Reviews Neurology 03/2010; 6(3): DOI: /nrneurol PhD Joaquim J. Ferreira MD, Dulce Neutel MD, Tiago Mestre MD, Miguel Coelho MD, Mário M. Rosa MD, PhD Olivier Rascol MD, PhD Cristina Sampaio MD: Skin Cancer and Parkinson's Disease. Movement Disorders 01/2010; 25(2): DOI: /mds L. Negre-Pages, S. Perez Lloret, P. Damier, A. Destee, F. Tison, C. Sampaio, J. Ferreira, P. Martinez Martin, O. Rascol: P3.135 Predictive factors for PD progression preliminary results of PARKMIP/COPARK cohort after 24-months follow up. Parkinsonism & Related Disorders 12/2009; 15. DOI: /S (09) T. F. Outeiro, Joaquim Ferreira: Current and Future Therapeutic Strategies for Parkinsons Disease. Current pharmaceutical design 12/2009; 15(34-34): DOI: / L. Correia Guedes, J.J. Ferreira, M.M. Rosa, M Coelho, V Bonifati, C Sampaio: Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review. Parkinsonism & Related Disorders 11/2009; 16(4): DOI: /j.parkreldis Henda Foreid, Miguel Coelho, Joaquim Ferreira, José M Ferro: Reversible iatrogenic subacute cerebellar syndrome, myoclonus and MRI findings following metronidazole administration. Case Reports 08/2009; DOI: /bcr Alessio Di Fonzo, Edito Fabrizio, Astrid Thomas, Emiliana Fincati, Roberto Marconi, Michele Tinazzi, Guido J Breedveld, Erik J Simons, Hsin F Chien, Joaquim J Ferreira, Martin W Horstink, Giovanni Abbruzzese, Barbara Borroni, Giovanni Cossu, Alessio Dalla Libera, Giovanni Fabbrini, Marco Guidi, Michele De Mari, Leonardo Lopiano, Emilia Martignoni, Paolo Marini, Marco Onofrj, Alessandro Padovani, Fabrizio Stocchi, Vincenzo Toni, Cristina Sampaio, Egberto R Barbosa, Giuseppe Meco, Ben A Oostra, Vincenzo Bonifati: GIGYF2 mutations are not a frequent cause of familial Parkinson's disease. Parkinsonism & Related Disorders 06/2009; 15(9): DOI: /j.parkreldis Liliana Olim Gouveia, Pedro Castanho, Joaquim J Ferreira: Safety of Chiropractic Interventions. Spine 06/2009; 34(11):E DOI: /BRS.0b013e3181a16d Elisa Vedes, Miguel Coelho, Joaquim J. Ferreira: P0394 RETRO-ORBITAL GRANULOMA AS A MANIFESTATION OF WEGENER'S GRANULOMATOSIS. European Journal of Internal Medicine 05/2009; 20. DOI: /S (09) Tiago Mestre, Joaquim J Ferreira, Samay Jain: A Multimodal Approach to Physical Therapy in Parkinson's Disease: Optimizing Strategies. Movement Disorders 04/2009; 24(6):946. DOI: /mds Tiago Mestre, Joaquim J. Ferreira: Eslicarbazepine acetate: A new option for the treatment of focal epilepsy. Expert Opinion on Investigational Drugs 03/2009; 18(2): DOI: / Tiago Mestre, Joaquim Ferreira, José Pimentel: Putaminal petechial haemorrhage as the cause of non-ketotic hyperglycaemic chorea: A neuropathological case correlated with MRI findings. Case Reports 02/2009; DOI: /bcr Tiago Mestre, Joaquim Ferreira, Miguel M Coelho, Mário Rosa, Cristina Sampaio: Therapeutic interventions for symptomatic treatment in Huntington's disease. Cochrane database of systematic reviews (Online) 02/2009; 3(3):CD DOI: / CD pub2

9 105. Tiago Mestre, Joaquim Ferreira, Miguel M Coelho, Mário Rosa, Cristina Sampaio: Therapeutic interventions for disease progression in Huntington's disease. Cochrane database of systematic reviews (Online) 02/2009; 3(3):CD DOI: / CD pub Rodrigo A Salinas, Gonzalo Alvarez, Joaquim Ferreira: WITHDRAWN: Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane database of systematic reviews (Online) 02/2009; DOI: / CD pub M. Coelho, A.F. Valadas, T. Mestre, J.J. Ferreira: Pain and quality of life in the treatment of cervical dystonia. European Neurological Review 01/2009; 4(2): DOI: /ENR Owen A Ross, Cleanthe Spanaki, Alida Griffith, Chin-Hsien Lin, Jennifer Kachergus, Kristoffer Haugarvoll, Helen Latsoudis, Andreas Plaitakis, Joaquim J Ferreira, Cristina Sampaio, Vincenzo Bonifati, Ruey-Meei Wu, Cyrus P Zabetian, Matthew J Farrer: Haplotype analysis of LRRK2 R1441H carriers with Parkinsonism. Parkinsonism & Related Disorders 11/2008; 15(6): DOI: /j.parkreldis L Silveira-Moriyama, L C Guedes, A Kingsbury, H Ayling, K Shaw, E R Barbosa, V Bonifati, N P Quinn, P Abou-Sleiman, N W Wood, A Petrie, C Sampaio, J J Ferreira, J Holton, T Revesz, A J Lees: Hyposmia in G2019S LRRK2-related parkinsonism - Clinical and pathologic data. Neurology 09/2008; 71(13): DOI: /01.wnl Daniel G Healy, Mario Falchi, Sean S O'Sullivan, Vincenzo Bonifati, Alexandra Durr, Susan Bressman, Alexis Brice, Jan Aasly, Cyrus P Zabetian, Stefano Goldwurm, Joaquim J Ferreira, Eduardo Tolosa, Denise M Kay, Christine Klein, David R Williams, Connie Marras, Anthony E Lang, Zbigniew K Wszolek, Jose Berciano, Anthony H V Schapira, Timothy Lynch, Kailash P Bhatia, Thomas Gasser, Andrew J Lees, Nicholas W Wood: International LRRK2 Consortium. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. The Lancet Neurology 08/2008; 7(7): DOI: /S (08) Moore Peter, Ferreira Joaquim, Pappert Eric: A 2-year open-label study of botulinum toxin type B in botulinum toxin type A resistant/responsive cervical dystonia patients (AN EUICD). Toxicon 06/2008; 51: DOI: /j.toxicon Pappert Eric, Germanson Terry, Moore A. Peter, Ferreira Joaquim: Botulinum toxin type A (Botox) versus botulinum toxin type B (Myobloc) in subjects with cervical dystonia: A comparison of the frequency of xerostomia and dysphagia (AN EU/CD). Toxicon 06/2008; 51: DOI: /j.toxicon Moore Peter, Ferreira Joaquim, Germanson Terry, Pappert Eric: Is treatment of cervical dystonia patients with botulinum toxin type B affected by a previous response to a botulinum toxin type A? Analysis of a long-term open-label study (AN EU/CD). Toxicon 06/2008; 51: DOI: /j.toxicon Ferreira Joaquim, Moore Peter, Pappert Eric: The effects of repeated dosing of botulinum toxin type B (neurobloc (R)) in patients with cervical dystonia previously naive to botulinum toxin: An open-label extension study (AN EU/CD). Toxicon 06/2008; 51: DOI: /j.toxicon Ricardo Fernandes, Joaquim J Ferreira, Cristina Sampaio: The Placebo Response in Studies of Acute Migraine. The Journal of pediatrics 05/2008; 152(4):527-33, 533.e1. DOI: /j.jpeds R L Stowe, N J Ives, Carl E Clarke, J van Hilten, Joaquim Ferreira, Robert J Hawker, Laila Shah, Keith Wheatley, Richard Gray: Dopamine agonist therapy in early Parkinson's disease. Cochrane database of systematic reviews (Online) 04/2008; 2(2):CD DOI: / CD pub João Costa, Maria Luz Rocha, Joaquim Ferreira, Teresinha Evangelista, Miguel Coelho, Mamede de Carvalho: Botulinum toxin type-b improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis. Journal of Neurology 04/2008; 255(4): DOI: /s Miguel Coelho, Joaquim Ferreira, Mário Rosa, Cristina Sampaio: Treatment options for non-motor symptoms in late-stage Parkinson's disease. Expert Opinion on Pharmacotherapy 04/2008; 9(4): DOI: / Joaquim J Ferreira, Luis Almeida, Luis Cunha, Marina Ticmeanu, Mário M Rosa, Cristina Januário, Cristina-Elena Mitu, Miguel Coelho, Leonor Correia- Guedes, Ana Morgadinho, Teresa Nunes, Lyndon C Wright, Amílcar Falcão, Cristina Sampaio, Patrício Soares-da-Silva: Effects of Nebicapone on Levodopa Pharmacokinetics, Catechol-O-methyltransferase Activity, and Motor Fluctuations in Patients with Parkinson Disease. Clinical neuropharmacology 01/2008; 31(1):2-18. DOI: /wnf.0b013e cb Liliana Olim Gouveia, Pedro Castanho, Joaquim J Ferreira, Miguel Moura Guedes, Filipa Falcão, Teresa Pinho e Melo: Chiropractic manipulation: Reasons for concern?. Clinical Neurology and Neurosurgery 01/2008; 109(10): DOI: /j.clineuro L. Almeida, J. Ferreira, T.Nunes, R. Machado, L. Torrão, J. Costa, E. Soares, J. Rocha, A. Falcão, L. Wright, P. Soares da Silva: Effect of nebicapone (BIA 3-202) on the pharmacokinetics of levodopa and catechol-o-methyltransferase (COMT) activity in patients with Parkinson s disease. British Journal of Clinical Pharmacology 12/2007; 63(6): A C Fonseca, J J Ferreira, L Albuquerque, J M Ferro: Sneeze as a precipitating factor of cerebral venous thrombosis. European Journal of Neurology 11/2007; 14(10):e7-8. DOI: /j x 123. M. Atadzhanov, P. Mwaba, Mamede de Carvalho, Joao Costa, Joaquim Ferreira: Upper limb tremor induced by peripheral nerve injury - Reply. Neurology 09/2007; 69(13): DOI: /01.wnl c 124. Joaquim Ferreira, João Maia Silva, Rita Freire, João Pignatelli, Leonor Correia Guedes, Alexandra Feijó, Mário Miguel Rosa, Miguel Coelho, João Costa, Ana Noronha, Russell Hewett, A Marques Gomes, J.L. Cirne de Castro, Olivier Rascol, Cristina Sampaio: Skin cancers and precancerous lesions in Parkinson's disease patients. Movement Disorders 07/2007; 22(10): DOI: /mds Joaquim J Ferreira, Leonor Correia Guedes, Mário Miguel Rosa, Miguel Coelho, Marina van Doeselaar, Dorothea Schweiger, Alessio Di Fonzo, Ben A Oostra, Cristina Sampaio, Vincenzo Bonifati: High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal. Movement Disorders 06/2007; 22(8): DOI: /mds Tiago A Mestre, Joaquim J Ferreira, José Pimentel: Putaminal petechial haemorrhage as the cause of non-ketotic hyperglycaemic chorea: A neuropathological case correlated with MRI findings [7]. Journal of neurology, neurosurgery, and psychiatry 06/2007; 78(5): DOI: /jnnp A Di Fonzo, H.F. Chien, Socal MM, Giraudo SB, Tassorelli CM, Iliceto GM, Fabbrini GM, Marconi RM, Fincati EM, Abbruzzese GM, P Marini, F Squitieri, M.W. Horstink, P Montagna, A Dalla Libera, F Stocchi, S Goldwurm, J.J. Ferreira, G Meco, E Martignoni, L Lopiano, L.B. Jardim, B.A. Oostra, E.R. Barbosa, V Bonifati: Di Fonzo, A. et al. ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology 68, Neurology 05/2007; 68(19): DOI: /01.wnl Joaquim J Ferreira, João Costa, Miguel Coelho, Cristina Sampaio: The management of cervical dystonia. Expert Opinion on Pharmacotherapy 03/2007; 8(2): DOI: / Joaquim Jos Ferreira, Cristina Sampaio: Essential tremor.. Clinical evidence 02/2007; Christopher G Goetz, Christine Hicking, Eugene Laska, Thomas Müller, C Warren Olanow, Hermann Russ, Bajaj, R. Barker, O. Blin, D. Burn, N. Carciumaru, A. Ceballos-Baumann, D. Constantin, A. Csanyi, L. Cunha, Philippe Damier, R. Dom, F. Durif, H. Fernandez, J. J. Ferreira, J. Fine, G. Gacs, D.

10 L. Giampaolo, R. Grunewald, P. Harcos, S. Horn, J. Jankovic, W. H. Jost, W. C. Koller, D. M. Lurie, W. R. W. Martin, I. G. Milanov, A. Moser, T. Müller, R. Pahwa, I. Pascu, R. Pfeiffer, Olivier Rascol, H. Reichmann, I. Sagi, A. Sahay, M. Saint-Hillaire, J. Schwarz, A. Serbanescu, K. D. Sethi, P. M. Shotekov, C. Singer, J. Smuts, P. Stamenova, A. Storch, J. W. Tetrud, J. Thorne, D. D. Truong, J. Tsui, S. I. Veleva, L. Verhagen, R. L. Watts, D. Woitalla, T. Zesiewicz: Sarizotan as a treatment for dyskinesias in Parkinson's disease: A double-blind placebo-controlled trial. Movement Disorders 02/2007; 22(2): DOI: /mds J Costa, R Henriques, C Barroso, J Ferreira, A Atalaia, M de Carvalho: Upper limb tremor induced by peripheral nerve injury. Neurology 12/2006; 67(10): DOI: /01.wnl b 132. Alessio Di Fonzo, Cristina Tassorelli, Michele De Mari, Hsin F Chien, Joaquim Ferreira, Christan F Rohé, Giulio Riboldazzi, Angelo Antonini, Gianni Albani, Alessandro Mauro, Roberto Marconi, Giovanni Abbruzzese, Leonardo Lopiano, Emiliana Fincati, Marco Guidi, Paolo Marini, Fabrizio Stocchi, Marco Onofrj, Vincenzo Toni, Michele Tinazzi, Giovanni Fabbrini, Paolo Lamberti, Nicola Vanacore, Giuseppe Meco, Petra Leitner, Ryan J Uitti, Zbigniew K Wszolek, Thomas Gasser, Erik J Simons, Guido J Breedveld, Stefano Goldwurm, Gianni Pezzoli, Cristina Sampaio, Egberto Barbosa, Emilia Martignoni, Ben A Oostra, Vincenzo Bonifati: Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. European Journal of HumanGenetics 04/2006; 14(3): DOI: /sj.ejhg J J Ferreira, K Desboeuf, M Galitzky, C Thalamas, C Brefel-Courbon, N Fabre, J-M Senard, J-L Montastruc, C Sampaio, O Rascol: Sleep disruption, daytime somnolence and 'sleep attacks' in Parkinson's disease: A clinical survey in PD patients and age-matched healthy volunteers. European Journal of Neurology 04/2006; 13(3): DOI: /j x 134. Ylmar Corrêa Neto, Francisco Cardoso, Antonio Lúcio Teixeira, Débora Palma Maia, Rogério Beato, Joaquim Ferreira: [The chorea of Zezé].. Acta medica portuguesa 03/2006; 19(2): F Geser, K Seppi, M Stampfer-Kountchev, M Köllensperger, A Diem, J P Ndayisaba, K Ostergaard, E Dupont, A Cardozo, E Tolosa, M Abele, R Dodel, T Klockgether, I Ghorayeb, F Yekhlef, F Tison, C Daniels, F Kopper, G Deuschl, M Coelho, J Ferreira, M M Rosa, C Sampaio, M Bozi, A Schrag, J Hooker, H Kim, T Scaravilli, C J Mathias, C Fowler, N Wood, N Quinn, H Widner, C F Nilsson, O Lindvall, N Schimke, K M Eggert, W Oertel, F del Sorbo, F Carella, A Albanese, M T Pellecchia, P Barone, R Djaldetti, G Meco, C Colosimo, A Gonzalez-Mandly, J Berciano, T Gurevich, N Giladi, M Galitzky, F Ory, O Rascol, C Kamm, K Buerk, S Maass, T Gasser, W Poewe, G K Wenning: The European Multiple System Atrophy-Study Group (EMSA-SG). Journal of Neural Transmission 01/2006; 112(12): DOI: /s y 136. Joaquim J Ferreira, Marina Couto, João Costa, Miguel Coelho, Mário M Rosa, Cristina Sampaio: [Botulinum toxin for the treatment of pain syndromes].. Acta reumatologica portuguesa 01/2006; 31(1): S Goldwurm, A Di Fonzo, E J Simons, C F Rohé, M Zini, M Canesi, S Tesei, A Zecchinelli, A Antonini, C Mariani, N Meucci, G Sacilotto, F Sironi, G Salani, J Ferreira, H F Chien, E Fabrizio, N Vanacore, A Dalla Libera, F Stocchi, C Diroma, P Lamberti, C Sampaio, G Meco, E Barbosa, A M Bertoli-Avella, G J Breedveld, BA Oostra, G Pezzoli, V Bonifati: The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. Journal of Medical Genetics 11/2005; 42(11):e65. DOI: /jmg J. Costa, C. Espírito-Santo, A. Borges, J. J. Ferreira, M. Coelho, P Moore, C. Sampaio: Botulinumtoxin Typ A versus Anticholinergika zur Behandlung der zervikalen Dystonie. Praxis 09/2005; 94(36): DOI: / J. Costa, C. Espírito-Santo, A. Borges, J. J. Ferreira, M. Coelho, P Moore, C. Sampaio: Botulinumtoxin Typ A zur Behandlung des Spasmus hemifacialis. Praxis 09/2005; 94(36): DOI: / J. Costa, C. Espírito-Santo, A. Borges, J. J. Ferreira, M. Coelho, P. Moore, C. Sampaio: Botulinumtoxin Typ B zur Behandlung der zervikalen Dystonie. Praxis 08/2005; 94(35): DOI: / João Costa, Cláudia C Espírito-Santo, Ana A Borges, J J Ferreira, Miguel M Coelho, Peter Moore, Cristina Sampaio: Botulinum toxin type A therapy for blepharospasm. Cochrane database of systematic reviews (Online) 02/2005; 1(1):CD DOI: / CD pub João Costa, Cláudia C Espírito-Santo, Ana A Borges, J J Ferreira, Miguel M Coelho, Peter Moore, Cristina Sampaio: Botulinum toxin type A therapy for hemifacial spasm. Cochrane database of systematic reviews (Online) 02/2005; DOI: / CD pub João Costa, Cláudia C Espírito-Santo, Ana A Borges, J J Ferreira, Miguel M Coelho, Peter Moore, Cristina Sampaio: Botulinum toxin type B for cervical dystonia. Cochrane database of systematic reviews (Online) 02/2005; 1(1):CD DOI: / CD pub João Costa, Ana A Borges, Cláudia C Espírito-Santo, Joaquim Ferreira, Miguel M Coelho, Peter Moore, Cristina Sampaio: Botulinum toxin type B for cervical dystonia. Cochrane database of systematic reviews (Online) 02/2005; 1(1):CD DOI: / CD pub J Costa, C Espírito-Santo, A Borges, J J Ferreira, M Coelho, C Sampaio: Botulinum toxin type A versus anticholinergics for cervical dystonia. Cochrane database of systematic reviews (Online) 02/2005; 1(1):CD DOI: / CD pub João Costa, Cláudia C Espírito-Santo, Ana A Borges, J.J. Ferreira, Miguel M Coelho, Peter Moore, Cristina Sampaio: Botulinum toxin type A therapy for cervical dystonia. Cochrane database of systematic reviews (Online) 02/2005; 1(1):CD DOI: / CD pub A Difonzo, C. F. Rohé, J Ferreira, H. F. Chien, L Vacca, F Stocchi, L Guedes, E Fabrizio, M Manfredi, N Vanacore: A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson s disease. The Lancet 01/2005; 365(9457): DOI: /S (05) Alessio Di Fonzo, Christan F Rohé, Joaquim Ferreira, Hsin F Chien, Laura Vacca, Fabrizio Stocchi, Leonor Guedes, Edito Fabrizio, Mario Manfredi, Nicola Vanacore, Stefano Goldwurm, Guido Breedveld, Cristina Sampaio, Giuseppe Meco, Egberto Barbosa, Ben A Oostra, Vincenzo Bonifati: Di Fonzo, A. et al. A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Lancet 365, The Lancet 01/2005; 365(9457): DOI: /S (05) Miguel Coelho, Joaquim José Ferreira, Beatriz Dias, Cristina Sampaio, Isabel Pavão Martins, Alexandre Castro-Caldas: Assessment of time perception: The effect of aging. Journal of the International Neuropsychological Society 06/2004; 10(3): DOI: /S Cristina Sampaio, João Costa, Joaquim J Ferreira: Clinical comparability of marketed formulations of botulinum toxin. Movement Disorders 04/2004; 19 Suppl 8(19 suppl 8):S DOI: /mds RA Salinas, Gonzalo Alvarez, Joaquim Ferreira: Corticosteroids for Bell's palsy (idiopathic facial paralysis) (Cochrane Review). Cochrane database of systematic reviews (Online) 02/2004; 4(4):CD DOI: / CD pub Olivier Rascol, C Brefel-Courbon, P Payoux, J Ferreira: The management of patients with early Parkinson's disease.. Advances in neurology 02/2003; 91: O Rascol, J J Ferreira, P Payoux, Ch Brefel-Courbon, J L Montastruc: Management of levodopa-induced dyskinesia. Revue Neurologique 01/2003; 158 Spec no 1(122):S Olivier Rascol, Pierre Payoux, Fabienne Ory, Joaquim J Ferreira, Christine Brefel-Courbon, Jean-Louis Montastruc: Limitations of current Parkinson's disease therapy. Annals of Neurology 01/2003; 53 Suppl 3(S3):S3-12; discussion S12-5. DOI: /ana R.A. Salinas, G. Alvarez, M.I. Alvarez, J. Ferreira: Kortikosteroide zur Behandlung der idiopathischen Fazialisparese (Bell'sche Parese). Praxis 12/2002; 91(51): DOI: /

11 156. O Rascol, P Payoux, J Ferreira, C Brefel-Courbon: The management of patients with early Parkinson's disease. Parkinsonism & Related Disorders 11/2002; 9(1):61-7. DOI: /S (02) Cristina Sampaio, Joaquim J Ferreira, João Costa: Evidence-based medicine (EBM) applied to Parkinson's disease treatment. Parkinsonism & Related Disorders 11/2002; 9(1):7-13. DOI: /S (02) Yoshio Tsuboi, Ryan J Uitti, Marie-Bernadette Delisle, Joaquim J Ferreira, Christine Brefel-Courbon, Olivier Rascol, Bernardino Ghetti, Jill R Murrell, Michael Hutton, Matthew Baker, Zbigniew K Wszolek: Clinical features and disease haplotypes of individuals with the N279K tau gene mutation - A comparison of the pallidopontonigral degeneration kindred and a French family. JAMA Neurology 07/2002; 59(6): DOI: /archneur Cristina Sampaio, Joaquim Ferreira: Essential tremor. Clinical evidence 07/2002; 12(7): J J Ferreira, M Galitzky, C Thalamas, M Tiberge, J L Montastruc, C Sampaio, O Rascol: Effect of ropinirole on sleep onset: A randomized, placebocontrolled study in healthy volunteers. Neurology 03/2002; 58(3): DOI: /WNL RA Salinas, G Alvarez, M I Alvarez, J Ferreira: Corticosteroids for Bell s Palsy (idiopathic facial paralysis). Cochrane database of systematic reviews (Online) 02/2002; 1(1):CD DOI: / CD J Costa, E I de Oliveira, M M Rosa, J J Ferreira, C Sampaio, A V Carneiro: [Cardiac effects of acute poisoning with tricyclic antidepressants: systematic review of the literature -- Part IV].. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 11/2001; 20(10): O Rascol, J Ferreira, J L Montastruc: [Abnormal diurnal somnolence, "sleep attacks" and antiparkinson drugs].. Revue Neurologique 11/2001; 157(10): J Costa, E I de Oliveira, M M Rosa, J J Ferreira, C Sampaio, A V Carneiro: [Cardiac effects of acute poisoning with tricyclic antidepressants: systematic review of the literature -- Part III].. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 10/2001; 20(9): J Costa, M M Rosa, J J Ferreira, C Sampaio, A Vaz Carneiro: [Cardiac effects of acute poisoning with tricyclic antidepressants: systematic review of the literature. Part I].. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 07/2001; 20(6): J.L. Montastruc, Christine Brefel-Courbon, J.M. Senard, Haleh Bagheri, Joaquim Ferreira, Olivier Rascol, Maryse Lapeyre-Mestre: Sleep Attacks and Antiparkinsonian Drugs: A Pilot Prospective Pharmacoepidemiologic Study. Clinical Neuropharmacology 05/2001; 24(3): DOI: / Jean-Louis Montastruc, Christine Brefel-Courbon, Jean-Michel Senard, Haleh Bagheri, Joaquim Ferreira, Olivier Rascol, Maryse Lapeyre-Mestre: Sleep Attacks and Antiparkinsonian Drugs: A Pilot Prospective Pharmacoepidemiologic Study. Clinical Neuropharmacology 04/2001; 24(3): Joaquim J. Ferreira, Claire Thalamas, Jean Louis Montastruc, Alexandre Castro-Caldas, Olivier Rascol: Levodopa monotherapy can induce sleep attacks in Parkinson's disease patients. Journal of Neurology 04/2001; 248(5): DOI: /s O Rascol, J J Ferreira, C Thalamas, M Galitsky, J L Montastruc: Dopamine agonists. Their role in the management of Parkinson's disease.. Advances in neurology 02/2001; 86: C Sampaio, J Ferreira, J Costa: [Numbers needed for treatment and their respective confidence intervals: useful tools to assess clinical significance and uncertainty associated with medical interventions].. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 01/2001; 19(12): T Warner, L Camfield, CD Marsden, AH Nemeth, N Hyman, D Harley, J Wissel, W Poewe, RJ Marttila, H Erjanti, P Burbaud, A Lagueny, C Kamm, T Gasser, D Franz, E Castelon-Konkiewitz, I Trender, A Ceballos-Baumann, A Nebe, B Freudenberg, A Bentivoglio, E Cassetta, A Albanese, A Curra, L Vacca, A Berardelli, J Ferreira, C Sampaio, V Passao, F Marti, E Tolosa, L Claveria, J Duarte, Y Ben-Shlomo, A Newton: A prevalence study of primary dystonia in eight European countries. Journal of Neurology 10/2000; 247(10): Joaquim J. Ferreira, Olivier Rascol: Prevention and therapeutic strategies for levodopa-induced dyskinesias in Parkinson's disease. Current Opinion in Neurology 09/2000; 13(4): DOI: / J Ferreira, M Galitzky, JL Montastruc, O Rascol: Sleep attacks in Parkinson's disease - Reply. The Lancet 08/2000; 356(9229):598. DOI: /S (05) J J Ferreira, M Galitzky, J L Montastruc, O Rascol: Sleep attacks and Parkinson's disease treatment. The Lancet 05/2000; 355(9212): DOI: /S (00)02119-X 175. J M Ferro, A N Pinto, I Falcão, G Rodrigues, J Ferreira, F Falcão, E Azevedo, P Canhão, T P Melo, M J Rosas, V Oliveira, A V Salgado: Diagnosis of Stroke by the Nonneurologist : A Validation Study. Stroke 07/1998; 29(6): DOI: /01.STR Cristina Sampaio, Joaquim J. Ferreira, Fernanda Simões, Maria J. Rosas, Marina Magalhães, Ana P. Correia, António Bastos-Lima, Rairnundo Martins, Alexandre Castro-Caldas: DYSBOT: A single-blind, randomized parallel study to determine whether any differences can be detected in the efficacy and tolerability of two formulations of Botulinum Toxin Type A - Dysport and Botox - assuming a ratio of 4:1. Movement Disorders 11/1997; 12(6): DOI: /mds Cristina Sampaio, Joaquim J Ferreira, Ana A Pinto, Crespo MC, José M Ferro, Alexandre Castro-Caldas: Botulinum toxin type A for the treatment of arm and hand spasticity in stroke patients.clin. Rehabil. 11, 3-7. Clinical Rehabilitation 03/1997; 11(1):3-7. DOI: / J.J. Ferreira, J.F. Rocha, A. Santos, T. Nunes, P. Soares-Da-Silva: The design of a double-blind, placebo- and active-controlled, multi-national phase-iii trial in patients with Parkinson's disease and end-of-dose motor fluctuations: Opicapone superiority vs. Placebo and non-inferiority vs. Entacapone J J Ferreira, C Sampaio: [Critical assessment of articles on controlled clinical trials II. Results].. Acta médica portuguesa 11(8-9): C Sampaio, J J Ferreira: [Critical assessment of articles on controlled clinical trials. I. Planning].. Acta médica portuguesa 11(8-9): C Sampaio, J J Ferreira: [Cochrane collaboration. What is it? What is it for? How does it contribute to the practice of evidence based medicine?].. Acta médica portuguesa 11(8-9): J Costa, E I de Oliveira, M M Rosa, J J Ferreira, C Sampaio, A V Carneiro: [Cardiac effects of acute poisoning with tricyclic antidepressants: systematic review of the literature -- Part II].. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 20(7-8):