Polymeric Nanoparticles in Drug Delivery

Transcrição

1 UNIVERSIDADE ESTADUAL DO CENTRO-OESTE Midwestern State University Polymeric Nanoparticles in Drug Delivery Associated professor Najeh Maissar Khalil Guarapuava - Paraná/Brazil

2 Guarapuava City UNICENTRO, Campus Central UNICENTRO, Campus CEDETEG Laboratory of Pharmaceutical Nanotechnology

3 POLYMERIC NANOPARTICLES IN DRUG DELIVERY Smaller size Higher surface area Higher drug bioavailability Low dose required Prolonged drug delivery Administered via different routes Ability to load hydrophilic or hydrophobic drugs Synthetic or natural polymers: biocompatible and biodegradable

4 Natural Products mproved neuroprotective effects of resveratrol-loaded olysorbate 80-coated poly(lactide) nanoparticles in MPTPnduced Parkinsonism. Nanomedicine, v. 10, p , Pharmacokinetics of Curcumin-loaded PLGA and PLGA-PEG Blend Nanoparticles After Oral Administration In Rats. Colloids and Surfaces. B, Biointerfaces (Print), v. 101, p , nfluence of the formulation parameters on the particle size and ncapsulation efficiency of resveratrol in PLA and PLA-PEG blend anoparticles: a factorial design. Journal of Nanoscience and anotechnology (Print), v. 15, p , esveratrol-loaded Polymeric Nanoparticles: Validation of an PLC-PDA Method to Determine the Drug Entrapment and valuation of Its Antioxidant Activity. The Scientific World ournal, v. 2013, p. 1-9, HBV/PCL Microparticles for Controlled Release of Resveratrol: hysicochemical Characterization, Antioxidant Potential and ffect on Hemolysis of Human Erythrocytes. The Scientific World ournal, v.., p , Development and validation of an HPLC method using fluorescence detection for the quantitative determination of curcumin from PLGA and PLGA-PEG nanoparticles. Current Pharmaceutical Analysis, v. 8, p , Nanoencapsulation of gallic acid and evaluation of its cytotoxicity and antioxidant activity. Materials Science and Engineering: C. v. 60, p , Bovine Serum Albumin Nanoparticles Containing Quercetin: Characterization and Antioxidant Activity. Journal of Nanoscience and Nanotechnology. v. 16, , 2016.

5 Amphotericin B Poly(L-lactide) Nanoparticles Reduce Amphotericin B Cytotoxicity and Maintain Its In Vitro Antifungal Activity. Journal of Nanoscience and Nanotechnology (Print), v. 15, p , Bovine serum albumin nanoparticles containing Amphotericin B: characterization, cytotoxicity and in vitro antifungal evaluation. Journal of Nanoscience and Nanotechnology (Print), v. 15, p , Amphotericin B-loaded polymeric nanoparticles: formulation optimization by factorial design. Pharmaceutical Development and Technology, p. 1-7, Nanotechnological Strategies for the Treatment of Neglected Diseases. Current Pharmaceutical Design (Print), v. 19, p , Amphotericin B-Loaded Poly(Lactide)-Poly(Ethylene Glycol)- Blend Nanoparticles: Characterization and In Vitro Efficacy and Toxicity. Current Nanoscience, v. 9, p , Antitumor drugs. Tamoxifen-loaded poly(l-lactide) nanoparticles: Development, characterization and in vitro evaluation of cytotoxicity. Materials Science and Engineering: C, V. 60, p , Development and validation of an HPLC method for the determination of fluorouracil in polymeric nanoparticles. Brazilian Journal of Pharmaceutical Sciences, v. 49, p , Development and validation of HPLC PDA method for the quantitative determination of Diphenyl diselenide in (Poly)lactide Nanoparticles. Current Pharmaceutical Analysis, v. 11, 2016.

6 Patents "'PROCESSO DE FORMULAÇÃO DE NANOPARTÍCULAS DE APOCININA (apocynin) REVESTIDAS COM O POLÍMERO NATURAL BSA E RETICULADAS COM GLUTARALDEÍDO PELO MÉTODO DE COACERVAÇÃO E FÁRMACO'", BR "PROCESSO DE FORMULAÇÃO DE NANOPARTÍCULAS POLIMÉRICAS DE HSA CONTENDO O COMPOSTO APOCININA (apocynin) POR NANO SPRAY DRYER E COM MODIFICAÇÃO DA SUPERFÍCIE ATRAVÉS DA INCORPORAÇÃO DO TENSOATIVO POLISSORBATO 80 (PS80)", BR "PROCESSO DE PRODUÇÃO DE NANOPARTÍCULAS POLIMÉRICAS CONTENDO O COMPOSTO ÁLCOOL PERÍLICO (perillyl alcohol) PELO MÉTODO DE EMULSIFICAÇÃO-EVAPORAÇÃO DO SOLVENTE E AS NANOPARTICULAS", BR 'PROCESSO DE OBTENÇÃO DE NANOPARTÍCULAS POLIMÉRICAS CONTENDO O FÁRMACO ANFOTERICINA B (amphotericin B)'. Protocolo: " PI "' PROCESSO DE OBTENÇÃO DE NANOPARTÍCULAS POLIMÉRICAS CONTENDO O FÁRMACO RESVERATROL, BR

7 Main Equipments

8 Pharmaceutical Nanotechnology Laboratory Research Leaders: Prof. Dr. Najeh Maissar Khalil (DT/CNPq Nanociências e Novos Materiais) Profa. Dra. Rubiana M. Mainardes (PQ/CNPq Biotecnologia) Post-Doctorates: Dra. Soraya Zaioncz Ph.D Students: Luciana Camargo, Daniel Brustolin, Ligia Pedroso, Isabela de Lima, Rebeca Caparica, Daniele Vieira, Graciela Vieira, Osmar Junior MSc. Student: Emili Antonio, Dyenifer Pereira, Suelen Ladwig, Michel Tereza

9 wwww.unicentro.br Najeh Maissar Khalil Rubiana Mara Mainardes cooperation

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12 Acknowledgment

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